Dengue: A Minireview

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2020 Aug 6

PMID 32751561

Citations 104

Authors

Harapan Harapan

Alice Michie

R Tedjo Sasmono

Allison Imrie

Affiliations

Soon will be listed here.

Abstract

Dengue, caused by infection of any of four dengue virus serotypes (DENV-1 to DENV-4), is a mosquito-borne disease of major public health concern associated with significant morbidity, mortality, and economic cost, particularly in developing countries. Dengue incidence has increased 30-fold in the last 50 years and over 50% of the world's population, in more than 100 countries, live in areas at risk of DENV infection. We reviews DENV biology, epidemiology, transmission dynamics including circulating serotypes and genotypes, the immune response, the pathogenesis of the disease as well as updated diagnostic methods, treatments, vector control and vaccine developments.

Citing Articles

Development of a multi-epitope vaccine candidate to combat SARS-CoV-2 and dengue virus co-infection through an immunoinformatic approach.

Mandal S, Chanu W, Natarajaseenivasan K Front Immunol. 2025; 16:1442101.

PMID: 40079004 PMC: 11897530. DOI: 10.3389/fimmu.2025.1442101.

Maternal and foetal outcomes in women with gestational Dengue: A systematic review.

Velez Jaramillo Y, Reveiz Montes M, Galvan-Barrios J, Picon-Jaimes Y Infez Med. 2025; 33(1):15-28.

PMID: 40071256 PMC: 11892438. DOI: 10.53854/liim-3301-3.

Whole genome sequencing and phylogenetic analysis of dengue virus in Central Nepal from 2022 to 2023.

Chi M, Katuwal N, Shrestha A, Madhup S, Tamrakar D, Shrestha R BMC Glob Public Health. 2025; 3(1):18.

PMID: 40045383 PMC: 11884168. DOI: 10.1186/s44263-025-00135-z.

Knowledge, Attitudes, and Practices for the Prevention and Vector Control of Dengue in a Colombian Rural Population: A Mixed Method Study.

Rossana L, Katty E, Mayra B SAGE Open Nurs. 2025; 11:23779608241302713.

PMID: 40013006 PMC: 11863257. DOI: 10.1177/23779608241302713.

Current Dengue Virus Vaccine Developments and Future Directions.

Anumanthan G, Sahay B, Mergia A Viruses. 2025; 17(2).

PMID: 40006967 PMC: 11861685. DOI: 10.3390/v17020212.

References

Perez A, Garcia G, Sierra B, Alvarez M, Vazquez S, Cabrera M . IL-10 levels in Dengue patients: some findings from the exceptional epidemiological conditions in Cuba. J Med Virol. 2004; 73(2):230-4. DOI: 10.1002/jmv.20080. View

Twiddy S, Holmes E, Rambaut A . Inferring the rate and time-scale of dengue virus evolution. Mol Biol Evol. 2003; 20(1):122-9. DOI: 10.1093/molbev/msg010. View

Yakob L, Funk S, Camacho A, Brady O, Edmunds W . Aedes aegypti Control Through Modernized, Integrated Vector Management. PLoS Curr. 2017; 9. PMC: 5319873. DOI: 10.1371/currents.outbreaks.45deb8e03a438c4d088afb4fafae8747. View

Capeding M, Tran N, Hadinegoro S, Ismail H, Chotpitayasunondh T, Chua M . Clinical efficacy and safety of a novel tetravalent dengue vaccine in healthy children in Asia: a phase 3, randomised, observer-masked, placebo-controlled trial. Lancet. 2014; 384(9951):1358-65. DOI: 10.1016/S0140-6736(14)61060-6. View

Ritchie S . Wolbachia and the near cessation of dengue outbreaks in Northern Australia despite continued dengue importations via travellers. J Travel Med. 2018; 25(1). DOI: 10.1093/jtm/tay084. View

Weaver S, Vasilakis N . Molecular evolution of dengue viruses: contributions of phylogenetics to understanding the history and epidemiology of the preeminent arboviral disease. Infect Genet Evol. 2009; 9(4):523-40. PMC: 3609037. DOI: 10.1016/j.meegid.2009.02.003. View

Kurosu T, Chaichana P, Yamate M, Anantapreecha S, Ikuta K . Secreted complement regulatory protein clusterin interacts with dengue virus nonstructural protein 1. Biochem Biophys Res Commun. 2007; 362(4):1051-6. DOI: 10.1016/j.bbrc.2007.08.137. View

Bogdan C . Nitric oxide and the immune response. Nat Immunol. 2001; 2(10):907-16. DOI: 10.1038/ni1001-907. View

Sabin A . The dengue group of viruses and its family relationships. Bacteriol Rev. 1950; 14(3):225-32. View

10.

Lanciotti R, Calisher C, Gubler D, Chang G, Vorndam A . Rapid detection and typing of dengue viruses from clinical samples by using reverse transcriptase-polymerase chain reaction. J Clin Microbiol. 1992; 30(3):545-51. PMC: 265106. DOI: 10.1128/jcm.30.3.545-551.1992. View

11.

Lambrechts L, Fansiri T, Pongsiri A, Thaisomboonsuk B, Klungthong C, Richardson J . Dengue-1 virus clade replacement in Thailand associated with enhanced mosquito transmission. J Virol. 2011; 86(3):1853-61. PMC: 3264336. DOI: 10.1128/JVI.06458-11. View

12.

Yu I, Zhang W, Holdaway H, Li L, Kostyuchenko V, Chipman P . Structure of the immature dengue virus at low pH primes proteolytic maturation. Science. 2008; 319(5871):1834-7. DOI: 10.1126/science.1153264. View

13.

Lanata C, Andrade T, Gil A, Terrones C, Valladolid O, Zambrano B . Immunogenicity and safety of tetravalent dengue vaccine in 2-11 year-olds previously vaccinated against yellow fever: randomized, controlled, phase II study in Piura, Peru. Vaccine. 2012; 30(41):5935-41. DOI: 10.1016/j.vaccine.2012.07.043. View

14.

Kuhn R, Zhang W, Rossmann M, Pletnev S, Corver J, Lenches E . Structure of dengue virus: implications for flavivirus organization, maturation, and fusion. Cell. 2002; 108(5):717-25. PMC: 4152842. DOI: 10.1016/s0092-8674(02)00660-8. View

15.

Flipse J, Diosa-Toro M, Hoornweg T, van de Pol D, Urcuqui-Inchima S, Smit J . Antibody-Dependent Enhancement of Dengue Virus Infection in Primary Human Macrophages; Balancing Higher Fusion against Antiviral Responses. Sci Rep. 2016; 6:29201. PMC: 4933910. DOI: 10.1038/srep29201. View

16.

Guzman M, Alvarez M, Halstead S . Secondary infection as a risk factor for dengue hemorrhagic fever/dengue shock syndrome: an historical perspective and role of antibody-dependent enhancement of infection. Arch Virol. 2013; 158(7):1445-59. DOI: 10.1007/s00705-013-1645-3. View

17.

da Costa V, Marques-Silva A, Floriano V, Moreli M . Safety, immunogenicity and efficacy of a recombinant tetravalent dengue vaccine: a meta-analysis of randomized trials. Vaccine. 2014; 32(39):4885-92. DOI: 10.1016/j.vaccine.2014.07.008. View

18.

Shu P, Su C, Liao T, Yang C, Chang S, Lin C . Molecular characterization of dengue viruses imported into Taiwan during 2003-2007: geographic distribution and genotype shift. Am J Trop Med Hyg. 2009; 80(6):1039-46. View

19.

Halstead S, Mahalingam S, Marovich M, Ubol S, Mosser D . Intrinsic antibody-dependent enhancement of microbial infection in macrophages: disease regulation by immune complexes. Lancet Infect Dis. 2010; 10(10):712-22. PMC: 3057165. DOI: 10.1016/S1473-3099(10)70166-3. View

20.

Gould E, de Lamballerie X, Zanotto P, Holmes E . Origins, evolution, and vector/host coadaptations within the genus Flavivirus. Adv Virus Res. 2003; 59:277-314. DOI: 10.1016/s0065-3527(03)59008-x. View