The Bioenergetics of Neuronal Morphogenesis and Regeneration: Frontiers Beyond the Mitochondrion

Overview

Journal Dev Neurobiol

Specialties Biology
Neurology

Date 2020 Aug 5

PMID 32750228

Citations 9

Authors

Gianluca Gallo

Affiliations

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Abstract

The formation of axons and dendrites during development, and their regeneration following injury, are energy intensive processes. The underlying assembly and dynamics of the cytoskeleton, axonal transport mechanisms, and extensive signaling networks all rely on ATP and GTP consumption. Cellular ATP is generated through oxidative phosphorylation (OxP) in mitochondria, glycolysis and "regenerative" kinase systems. Recent investigations have focused on the role of the mitochondrion in axonal development and regeneration emphasizing the importance of this organelle and OxP in axon development and regeneration. In contrast, the understanding of alternative sources of ATP in neuronal morphogenesis and regeneration remains largely unexplored. This review focuses on the current state of the field of neuronal bioenergetics underlying morphogenesis and regeneration and considers the literature on the bioenergetics of non-neuronal cell motility to emphasize the potential contributions of non-mitochondrial energy sources.

Citing Articles

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Neuronal glycolysis: focus on developmental morphogenesis and localized subcellular functions.

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Actin(g) toward a revised understanding of the role of cytoskeletal dynamics in neuronal bioenergetics.

Holland S, Gallo G Neural Regen Res. 2024; 19(10):2109-2110.

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NMNAT2 supports vesicular glycolysis via NAD homeostasis to fuel fast axonal transport.

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Actin cytoskeletal dynamics do not impose an energy drain on growth cone bioenergetics.

Holland S, Gallo G J Cell Sci. 2023; 136(16).

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