Congenital Cataract - Clinical and Morphological Aspects

Overview

Journal Rom J Morphol Embryol

Specialties Anatomy & Histology
Cell Biology
Reproductive Medicine

Date 2020 Aug 5

PMID 32747900

Citations 10

Authors

Catalina Ioana Tataru

Catalin Petru Tataru

Adrian Costache

Ovidiu Boruga

Mihail Zemba

Radu Constantin Ciuluvica

George Sima

Affiliations

Soon will be listed here.

Abstract

Congenital cataract is one of the main causes of blindness in newborns and children. According to the World Health Organization (WHO), there are about 14 million children suffering from congenital cataract. Our study is based on 82 children, males - 46 (56.1%) and females - 36 (43.9%), with congenital cataract operated in the same ophthalmological centre in Bucharest, Romania. Of the 82 patients, 49 (59.76%) had bilateral cataract and 33 (40.24%) unilateral cataract. Clinically, the most frequent was the total cataract, followed by lamellar, nuclear and cerulean. We employed nine surgical approaches in our patients, depending on the type of intraocular lens (IOL). Morphologically, obvious changes were rendered evident at the level of anterior and posterior capsules, as well as subcapsular.

Citing Articles

Histopathological Analysis of Pseudoexfoliation Material in Ocular Surgeries: Clinical Implications.

Stejar L, Istrate-Ofiteru A, Tofolean I, Preoteasa D, Balta F Diagnostics (Basel). 2024; 14(19).

PMID: 39410590 PMC: 11475199. DOI: 10.3390/diagnostics14192187.

Sutural Cataract Associated With Pupillary Membrane: A Case Report of an Unusual Relation.

Saucedo Rizo J, Hernandez Rodriguez O Cureus. 2024; 16(9):e69027.

PMID: 39385854 PMC: 11464097. DOI: 10.7759/cureus.69027.

Novel gene mutation causes autosomal-dominant congenital cataract.

Ni J, Wen H, Huang X, Li Q, Cai J, Fan B Int J Ophthalmol. 2024; 17(3):454-465.

PMID: 38721506 PMC: 11074161. DOI: 10.18240/ijo.2024.03.06.

Challenges of Secondary Glaucoma Management Following Congenital Cataract Surgery, Penetrating Keratoplasty and Vitreoretinal Surgery.

Coviltir V, Marinescu M, Burcel M, Cerghedean-Florea M, Hasegan A, Tanasescu C Diagnostics (Basel). 2024; 14(8).

PMID: 38667482 PMC: 11049643. DOI: 10.3390/diagnostics14080837.

Straatsma Syndrome and cataract: case report and review of the literature.

Blanca C, Isabel P, Sergio I, Candela C, Honorio B, Enrique E Rom J Ophthalmol. 2024; 67(4):416-418.

PMID: 38239417 PMC: 10793372. DOI: 10.22336/rjo.2023.67.

References

Berry V, Georgiou M, Fujinami K, Quinlan R, Moore A, Michaelides M . Inherited cataracts: molecular genetics, clinical features, disease mechanisms and novel therapeutic approaches. Br J Ophthalmol. 2020; 104(10):1331-1337. DOI: 10.1136/bjophthalmol-2019-315282. View

Song Z, Si N, Xiao W . A novel mutation in the CRYAA gene associated with congenital cataract and microphthalmia in a Chinese family. BMC Med Genet. 2018; 19(1):190. PMC: 6194747. DOI: 10.1186/s12881-018-0695-5. View

Song S, Landsbury A, Dahm R, Liu Y, Zhang Q, Quinlan R . Functions of the intermediate filament cytoskeleton in the eye lens. J Clin Invest. 2009; 119(7):1837-48. PMC: 2701874. DOI: 10.1172/JCI38277. View

Holmes J, Leske D, Burke J, Hodge D . Birth prevalence of visually significant infantile cataract in a defined U.S. population. Ophthalmic Epidemiol. 2003; 10(2):67-74. DOI: 10.1076/opep.10.2.67.13894. View

Chen P, Tsai P, Cheng Y, Lee C, Chang C . Congenital cataracts diagnosed by prenatal ultrasound. Taiwan J Obstet Gynecol. 2015; 54(4):461-2. DOI: 10.1016/j.tjog.2015.06.004. View

Raju I, Abraham E . Congenital cataract causing mutants of αA-crystallin/sHSP form aggregates and aggresomes degraded through ubiquitin-proteasome pathway. PLoS One. 2011; 6(11):e28085. PMC: 3226672. DOI: 10.1371/journal.pone.0028085. View

Reddy M, Francis P, Berry V, Bhattacharya S, Moore A . Molecular genetic basis of inherited cataract and associated phenotypes. Surv Ophthalmol. 2004; 49(3):300-15. DOI: 10.1016/j.survophthal.2004.02.013. View

Haargaard B, Wohlfahrt J, Fledelius H, Rosenberg T, Melbye M . A nationwide Danish study of 1027 cases of congenital/infantile cataracts: etiological and clinical classifications. Ophthalmology. 2004; 111(12):2292-8. DOI: 10.1016/j.ophtha.2004.06.024. View

Lampi K, Ma Z, Shih M, Shearer T, Smith J, Smith D . Sequence analysis of betaA3, betaB3, and betaA4 crystallins completes the identification of the major proteins in young human lens. J Biol Chem. 1997; 272(4):2268-75. DOI: 10.1074/jbc.272.4.2268. View

10.

Liu Q, Zhu S . Clinical characteristics of congenital lamellar cataract and myopia in a Chinese family. Biosci Rep. 2020; 40(2). PMC: 7024846. DOI: 10.1042/BSR20191349. View

11.

Das S, Khanna R, Mohiuddin S, Ramamurthy B . Surgical and visual outcomes for posterior polar cataract. Br J Ophthalmol. 2008; 92(11):1476-8. DOI: 10.1136/bjo.2007.129403. View

12.

Osher R, Yu B, Koch D . Posterior polar cataracts: a predisposition to intraoperative posterior capsular rupture. J Cataract Refract Surg. 1990; 16(2):157-62. DOI: 10.1016/s0886-3350(13)80724-9. View

13.

Costache A, Dumitru M, Anghel I, Cergan R, Anghel A, Sarafoleanu C . Ultrasonographic anatomy of head and neck--a pictorial for the ENT specialist. Med Ultrason. 2015; 17(1):104-8. DOI: 10.11152/mu.2013.2066.171.aco. View

14.

Mohammadpour M, Shaabani A, Sahraian A, Momenaei B, Tayebi F, Bayat R . Updates on managements of pediatric cataract. J Curr Ophthalmol. 2019; 31(2):118-126. PMC: 6611931. DOI: 10.1016/j.joco.2018.11.005. View

15.

Barraquer R, Michael R, Abreu R, Lamarca J, Tresserra F . Human lens capsule thickness as a function of age and location along the sagittal lens perimeter. Invest Ophthalmol Vis Sci. 2006; 47(5):2053-60. DOI: 10.1167/iovs.05-1002. View

16.

Amaya L, Taylor D, Russell-Eggitt I, Nischal K, Lengyel D . The morphology and natural history of childhood cataracts. Surv Ophthalmol. 2003; 48(2):125-44. DOI: 10.1016/s0039-6257(02)00462-9. View

17.

Churchill A, Graw J . Clinical and experimental advances in congenital and paediatric cataracts. Philos Trans R Soc Lond B Biol Sci. 2011; 366(1568):1234-49. PMC: 3061104. DOI: 10.1098/rstb.2010.0227. View

18.

Siatiri H, Moghimi S . Posterior polar cataract: minimizing risk of posterior capsule rupture. Eye (Lond). 2005; 20(7):814-6. DOI: 10.1038/sj.eye.6702023. View

19.

Medsinge A, Nischal K . Pediatric cataract: challenges and future directions. Clin Ophthalmol. 2015; 9:77-90. PMC: 4293928. DOI: 10.2147/OPTH.S59009. View

20.

Augusteyn R . On the growth and internal structure of the human lens. Exp Eye Res. 2010; 90(6):643-54. PMC: 2871961. DOI: 10.1016/j.exer.2010.01.013. View