Ferroptosis-Related Gene Signature Predicts Glioma Cell Death and Glioma Patient Progression

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2020 Aug 1

PMID 32733879

Citations 94

Authors

Han-Jie Liu

Hui-Min Hu

Guan-Zhang Li

Ying Zhang

Fan Wu

Xiu Liu

Kuan-Yu Wang

Chuan-bao Zhang

Tao Jiang

Affiliations

Soon will be listed here.

Abstract

Glioma is a fatal brain tumor characterized by rapid proliferation and treatment resistance. Ferroptosis is a newly discovered programmed cell death and plays a crucial role in the occurrence and progression of tumors. In this study, we identified ferroptosis specific markers to reveal the relationship between ferroptosis-related genes and glioma by analyzing whole transcriptome data from Chinese Glioma Genome Atlas, The Cancer Genome Atlas dataset, GSE16011 dataset, and the Repository of Molecular Brain Neoplasia Data dataset. Nineteen ferroptosis-related genes with clinical and pathological features of glioma were identified as highly correlated. Functional assays in glioma cell lines indicated the association of ferroptosis with temozolomide resistance, autophagy, and glioma cell migration. Therefore, the identified ferroptosis-related genes were significantly correlated with glioma progression.

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