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Fusion of the CRM1 Nuclear Export Receptor to AF10 Causes Leukemia and Transcriptional Activation of HOXA Genes

Overview
Journal Leukemia
Specialties Hematology
Oncology
Date 2020 Aug 1
PMID 32733011
Citations 3
Authors
Waitman K Aumann
Jessica L Heath
Amanda E Conway
Sei-Gyung Kim Sze
Veerain K Gupta
Rafi R Kazi
Donald R Tope
Daniel S Wechsler
Catherine P Lavau
Affiliations
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Novel-and Not So Novel-Inhibitors of the Multifunctional CRM1 Protein.

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Exportin-1 functions as an adaptor for transcription factor-mediated docking of chromatin at the nuclear pore complex.

Ge T, Brickner D, Zehr K, VanBelzen D, Zhang W, Caffalette C bioRxiv. 2024; .

PMID: 38798450 PMC: 11118273. DOI: 10.1101/2024.05.09.593355.

MOZ/ENL complex is a recruiting factor of leukemic AF10 fusion proteins.

Komata Y, Kanai A, Maeda T, Inaba T, Yokoyama A Nat Commun. 2023; 14(1):1979.

PMID: 37031220 PMC: 10082848. DOI: 10.1038/s41467-023-37712-5.