A Plot TWIST in Pulmonary Arterial Hypertension

Overview

Journal Am J Respir Crit Care Med

Specialty Critical Care

Date 2020 Jul 31

PMID 32730129

Authors

Kevin Misner

Daniel J Kass

Affiliations

Soon will be listed here.

References

Spiekerkoetter E, Kawut S, de Jesus Perez V . New and Emerging Therapies for Pulmonary Arterial Hypertension. Annu Rev Med. 2018; 70:45-59. PMC: 7735523. DOI: 10.1146/annurev-med-041717-085955. View

Deng Z, Morse J, Slager S, Cuervo N, Moore K, Venetos G . Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene. Am J Hum Genet. 2000; 67(3):737-44. PMC: 1287532. DOI: 10.1086/303059. View

Weathington N, Sznajder J, Mallampalli R . The emerging role of the ubiquitin proteasome in pulmonary biology and disease. Am J Respir Crit Care Med. 2013; 188(5):530-7. PMC: 3827704. DOI: 10.1164/rccm.201304-0754PP. View

Mammoto T, Muyleart M, Konduri G, Mammoto A . Twist1 in Hypoxia-induced Pulmonary Hypertension through Transforming Growth Factor-β-Smad Signaling. Am J Respir Cell Mol Biol. 2017; 58(2):194-207. DOI: 10.1165/rcmb.2016-0323OC. View

Huang X, Dixit V . Drugging the undruggables: exploring the ubiquitin system for drug development. Cell Res. 2016; 26(4):484-98. PMC: 4822129. DOI: 10.1038/cr.2016.31. View

Tisato V, Voltan R, Gonelli A, Secchiero P, Zauli G . MDM2/X inhibitors under clinical evaluation: perspectives for the management of hematological malignancies and pediatric cancer. J Hematol Oncol. 2017; 10(1):133. PMC: 5496368. DOI: 10.1186/s13045-017-0500-5. View

Bridges R, Kass D, Loh K, Glackin C, Borczuk A, Greenberg S . Gene expression profiling of pulmonary fibrosis identifies Twist1 as an antiapoptotic molecular "rectifier" of growth factor signaling. Am J Pathol. 2009; 175(6):2351-61. PMC: 2789617. DOI: 10.2353/ajpath.2009.080954. View

Li S, Wang A, Gu F, Wang Z, Tian C, Qian Z . Novel harmine derivatives for tumor targeted therapy. Oncotarget. 2015; 6(11):8988-9001. PMC: 4496197. DOI: 10.18632/oncotarget.3276. View

Meiners S, Evankovich J, Mallampalli R . The ubiquitin proteasome system as a potential therapeutic target for systemic sclerosis. Transl Res. 2018; 198:17-28. PMC: 10231402. DOI: 10.1016/j.trsl.2018.03.003. View

10.

Tan J, Tedrow J, Nouraie M, Dutta J, Miller D, Li X . Loss of Twist1 in the Mesenchymal Compartment Promotes Increased Fibrosis in Experimental Lung Injury by Enhanced Expression of CXCL12. J Immunol. 2017; 198(6):2269-2285. PMC: 5337810. DOI: 10.4049/jimmunol.1600610. View

11.

Bourgeois A, Omura J, Habbout K, Bonnet S, Boucherat O . Pulmonary arterial hypertension: New pathophysiological insights and emerging therapeutic targets. Int J Biochem Cell Biol. 2018; 104:9-13. DOI: 10.1016/j.biocel.2018.08.015. View

12.

Wang C, Ying L, Barnes E, Adams E, Kim F, Engel K . Pulmonary artery smooth muscle cell HIF-1α regulates endothelin expression via microRNA-543. Am J Physiol Lung Cell Mol Physiol. 2018; 315(3):L422-L431. PMC: 6172620. DOI: 10.1152/ajplung.00475.2017. View

13.

Yochum Z, Cades J, Mazzacurati L, Neumann N, Khetarpal S, Chatterjee S . A First-in-Class TWIST1 Inhibitor with Activity in Oncogene-Driven Lung Cancer. Mol Cancer Res. 2017; 15(12):1764-1776. PMC: 5712248. DOI: 10.1158/1541-7786.MCR-17-0298. View

14.

Fan Y, Gu X, Zhang J, Sinn K, Klepetko W, Wu N . TWIST1 Drives Smooth Muscle Cell Proliferation in Pulmonary Hypertension via Loss of GATA-6 and BMPR2. Am J Respir Crit Care Med. 2020; 202(9):1283-1296. DOI: 10.1164/rccm.201909-1884OC. View

15.

Yochum Z, Cades J, Wang H, Chatterjee S, Simons B, OBrien J . Targeting the EMT transcription factor TWIST1 overcomes resistance to EGFR inhibitors in EGFR-mutant non-small-cell lung cancer. Oncogene. 2018; 38(5):656-670. PMC: 6358506. DOI: 10.1038/s41388-018-0482-y. View

16.

Pullamsetti S, Savai R, Seeger W, Goncharova E . Translational Advances in the Field of Pulmonary Hypertension. From Cancer Biology to New Pulmonary Arterial Hypertension Therapeutics. Targeting Cell Growth and Proliferation Signaling Hubs. Am J Respir Crit Care Med. 2016; 195(4):425-437. PMC: 5803657. DOI: 10.1164/rccm.201606-1226PP. View

17.

Thenappan T, Ormiston M, Ryan J, Archer S . Pulmonary arterial hypertension: pathogenesis and clinical management. BMJ. 2018; 360:j5492. PMC: 6889979. DOI: 10.1136/bmj.j5492. View