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T Cell Responses in Patients with COVID-19

Overview
Journal Nat Rev Immunol
Date 2020 Jul 31
PMID 32728222
Citations 489
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Abstract

The role of T cells in the resolution or exacerbation of COVID-19, as well as their potential to provide long-term protection from reinfection with SARS-CoV-2, remains debated. Nevertheless, recent studies have highlighted various aspects of T cell responses to SARS-CoV-2 infection that are starting to enable some general concepts to emerge.

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References
1.
Paich H, Sheridan P, Handy J, Karlsson E, Schultz-Cherry S, Hudgens M . Overweight and obese adult humans have a defective cellular immune response to pandemic H1N1 influenza A virus. Obesity (Silver Spring). 2013; 21(11):2377-86. PMC: 3695020. DOI: 10.1002/oby.20383. View

2.
Weiskopf D, Schmitz K, Raadsen M, Grifoni A, Okba N, Endeman H . Phenotype and kinetics of SARS-CoV-2-specific T cells in COVID-19 patients with acute respiratory distress syndrome. Sci Immunol. 2020; 5(48). PMC: 7319493. DOI: 10.1126/sciimmunol.abd2071. View

3.
Bottcher J, Schanz O, Garbers C, Zaremba A, Hegenbarth S, Kurts C . IL-6 trans-signaling-dependent rapid development of cytotoxic CD8+ T cell function. Cell Rep. 2014; 8(5):1318-27. DOI: 10.1016/j.celrep.2014.07.008. View

4.
Defuria J, Belkina A, Jagannathan-Bogdan M, Snyder-Cappione J, Carr J, Nersesova Y . B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile. Proc Natl Acad Sci U S A. 2013; 110(13):5133-8. PMC: 3612635. DOI: 10.1073/pnas.1215840110. View

5.
Frebel H, Nindl V, Schuepbach R, Braunschweiler T, Richter K, Vogel J . Programmed death 1 protects from fatal circulatory failure during systemic virus infection of mice. J Exp Med. 2012; 209(13):2485-99. PMC: 3526355. DOI: 10.1084/jem.20121015. View