Clinical Outcomes of Microdissection Testicular Sperm Extraction-intracytoplasmic Sperm Injection with Fresh or Cryopreserved Sperm in Patients with Nonobstructive Azoospermia

Overview

Journal Asian J Androl

Specialty Urology

Date 2020 Jul 29

PMID 32719193

Citations 8

Authors

Hong-Liang Zhang

Jia-Ming Mao

De-Feng Liu

Lian-Ming Zhao

Wen-Hao Tang

Kai Hong

Li Zhang

Ying Lian

Hao-Cheng Lin

Hui Jiang

Affiliations

Soon will be listed here.

Abstract

We performed this study to evaluate the clinical outcomes of microdissection testicular sperm extraction-intracytoplasmic sperm injection (micro-TESE-ICSI) treatment that used fresh or cryopreserved sperm in patients with nonobstructive azoospermia (NOA). A total of 338 NOA patients with 344 consecutive cycles received treatment in the reproductive medicine center of Peking University Third Hospital in Beijing, China, from January 2014 to December 2017. Fresh oocytes and fresh sperm were used in 222 patients with 234 cycles (Group A). Fresh oocytes and cryopreserved sperm were used in 116 patients with 110 cycles (Group B). We compared patient characteristics, embryonic development, and pregnancy outcomes between Groups A and B. There was no statistical difference in the patient characteristics, and no differences were observed with fertilization or quality embryo rates between Groups A and B. The rates of clinical pregnancy and live birth were both higher for Group A than those for Group B (both P < 0.05). In conclusion, fresh testicular sperm appears to produce better ICSI outcomes than cryopreserved testicular sperm in patients with NOA.

Citing Articles

Critical appraisal of 'pregnancy outcomes in patients with non-obstructive azoospermia undergoing micro-TESE: comparison of fresh vs. frozen-thawed testicular sperm'.

Elzeiny H J Assist Reprod Genet. 2025; .

PMID: 39976775 DOI: 10.1007/s10815-025-03419-3.

Revisiting non-obstructive azoospermia: Is there a best way to retrieve testicular sperm?.

Kanto S, Ichioka K, Sato Y, Uchino Y, Tanaka T, Endo M Reprod Med Biol. 2025; 24(1):e12632.

PMID: 39917553 PMC: 11799768. DOI: 10.1002/rmb2.12632.

Effect of freezing and thawing on ejaculated sperm and subsequent pregnancy and neonatal outcomes in IVF.

Xie Q, Jiang X, Zhao M, Xie Y, Fan Y, Suo L Front Endocrinol (Lausanne). 2024; 15:1408662.

PMID: 39736859 PMC: 11684094. DOI: 10.3389/fendo.2024.1408662.

Pregnancy outcomes in patients with non-obstructive azoospermia undergoing micro-TESE: comparison of fresh vs. frozen-thawed testicular sperm.

Suleymanova L, Bayram H, Donmez Cakil Y, Selam B, Cincik M J Assist Reprod Genet. 2024; 41(12):3399-3404.

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Comparison of obstetrical and neonatal outcomes between fresh versus frozen-thawed testicular sperm derived from microTESE.

Nagawkar Perlov S, Deri N, Eldar-Geva T, Gal M, Reichman O, Or Y J Assist Reprod Genet. 2024; 41(10):2681-2690.

PMID: 39331312 PMC: 11535137. DOI: 10.1007/s10815-024-03265-9.

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