ADAM10 Mediates Ectopic Proximal Tubule Development and Renal Fibrosis Through Notch Signalling

Overview

Journal J Pathol

Specialty Pathology

Date 2020 Jul 28

PMID 32715474

Citations 14

Authors

Bingjue Li

Chaohong Zhu

Lihua Dong

Jing Qin

Wenyu Xiang

Alan J Davidson

Shi Feng

Yucheng Wang

Xiujin Shen

Chunhua Weng

Cuili Wang

Tingting Zhu

Lisha Teng

Junwen Wang

Christoph Englert

Jianghua Chen

Hong Jiang

Affiliations

Soon will be listed here.

Abstract

Disturbed intrauterine development increases the risk of renal disease. Various studies have reported that Notch signalling plays a significant role in kidney development and kidney diseases. A disintegrin and metalloproteinase domain 10 (ADAM10), an upstream protease of the Notch pathway, is also reportedly involved in renal fibrosis. However, how ADAM10 interacts with the Notch pathway and causes renal fibrosis is not fully understood. In this study, using a prenatal chlorpyrifos (CPF) exposure mouse model, we investigated the role of the ADAM10/Notch axis in kidney development and fibrosis. We found that prenatal CPF-exposure mice presented overexpression of Adam10, Notch1 and Notch2, and led to premature depletion of Six2 nephron progenitors and ectopic formation of proximal tubules (PTs) in the embryonic kidney. These abnormal phenotypic changes persisted in mature kidneys due to the continuous activation of ADAM10/Notch and showed aggravated renal fibrosis in adults. Finally, both ADAM10 and NOTCH2 expression were positively correlated with the degree of renal interstitial fibrosis in IgA nephropathy patients, and increased ADAM10 expression was negatively correlated with decreased kidney function evaluated by serum creatinine, cystatin C, and estimated glomerular filtration rate. Regression analysis also indicated that ADAM10 expression was an independent risk factor for fibrosis in IgAN. © 2020 The Authors. The Journal of Pathology published by John Wiley & Sons, Ltd. on behalf of The Pathological Society of Great Britain and Ireland.

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