Treatment Efficacy of Chuang Ling Ye, a Traditional Chinese Herbal Medicine Compound, on Idiopathic Granulomatous Mastitis: A Randomized Controlled Trial

Overview

Journal Evid Based Complement Alternat Med

Specialty Rehabilitation Medicine

Date 2020 Jul 28

PMID 32714413

Citations 3

Authors

Jing-Xian Xue

Bei Ye

Shun Liu

Si-Han Cao

Wei-He Bian

Chang Yao

Affiliations

Soon will be listed here.

Abstract

Objective: To explore whether Chuang Ling Ye (CLY), a traditional Chinese herbal medicine compound, could improve the treatment of idiopathic granulomatous mastitis (IGM) via decreasing inflammatory response.

Methods: Herein, 40 patients with IGM who had wounds requiring dressing change were enrolled and randomly divided into two groups: the CLY group and the control group. The size of the neoplasm and pain score of patients were followed-up for 4 weeks. Local tissues were taken during dressing change and examined by commercial enzyme-linked immunosorbent assay (ELISA) kits. The levels of inflammatory markers, including interleukin-1 (IL-1), IL-2, IL-6, interferon gamma (IFN-), and tumor necrosis factor- (TNF-) were measured.

Results: After treatment, the size of the neoplasm in the CLY group was significantly smaller than that in the control group (14.28 cm ± 8.96 cm vs. 21.14 cm ± 0.12 cm, =0.038), and the pain scores were markedly reduced (=0.004). Besides, CLY downregulated the expression levels of IL-1, IFN-, and TNF-.

Conclusion: External use of CLY could reduce the neoplasm of IGM by inhibiting local inflammation. This trial is registered with ChiCTR1800017744.

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