PE_PGRS Proteins of : A Specialized Molecular Task Force at the Forefront of Host-pathogen Interaction

Overview

Journal Virulence

Specialty Microbiology

Date 2020 Jul 28

PMID 32713249

Citations 29

Authors

Flavio De Maio

Rita Berisio

Riccardo Manganelli

Giovanni Delogu

Affiliations

Soon will be listed here.

Abstract

To the PE_PGRS protein subfamily belongs a group of surface-exposed mycobacterial antigens that in () H37Rv accounts to more than 65 genes, 51 of which are thought to express a functional protein. PE_PGRS proteins share a conserved structural architecture with three main domains: the N-terminal PE domain; the PGRS domain, that can vary in sequence and size and is characterized by the presence of multiple GGA-GGX amino acid repeats; the highly conserved sequence containing the GRPLI motif that links the PE and PGRS domains; the unique C-terminus end that can vary in size from few to up to ≈ 300 amino acids. genes emerged in slow-growing mycobacteria and expanded and diversified in MTBC and few other pathogenic mycobacteria. Interestingly, despite sequence homology and apparent redundancy, PE_PGRS proteins seem to have evolved a peculiar function. In this review, we summarize the actual knowledge on this elusive protein family in terms of evolution, structure, and function, focusing on the role of PE_PGRS in TB pathogenesis. We provide an original hypothesis on the role of the PE domain and propose a structural model for the polymorphic PGRS domain that might explain how so similar proteins can have different physiological functions.

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