Comorbid Diabetes and the Risk of Disease Severity or Death Among 8807 COVID-19 Patients in China: A Meta-analysis

Overview

Journal Diabetes Res Clin Pract

Specialty Endocrinology

Date 2020 Jul 26

PMID 32710998

Citations 51

Authors

Li Guo

Zumin Shi

Ya Zhang

Cuicui Wang

Nayla Cristina do Vale Moreira

Hui Zuo

Akhtar Hussain

Affiliations

Soon will be listed here.

Abstract

Aims: Diabetes mellitus has been reported to be one of the most prevalent comorbidity in patients with Coronavirus Disease 2019 (COVID-19). We aimed to assess the association of comorbid diabetes with COVID-19 severity or mortality in China.

Methods: We performed a systematic literature search from six electronic databases on diabetes and COVID-19. The outcome of interest was disease severity or mortality. Heterogeneity among the studies was assessed by the Cochran Q test and the I statistic. A random effects model was applied to calculate the pooled risk ratio (RR) with 95% confidence interval (CI).

Results: Nine studies from different provinces/cities were identified according to the predefined inclusion and exclusion criteria. There were a total of 1070 patients with diabetes, out of the 8807 COVID-19 cases. The majority of the cases were derived from Hubei Province. A low degree of heterogeneity in the risk estimates was observed in the included studies. Meta-analysis showed that there was a significant association of preexisting diabetes with disease severity or death. The pooled RR was 2.96 (95% CI: 2.31-3.79; p < 0.001). Sensitivity analysis demonstrated no significant changes in the pooled estimates.

Conclusions: Comorbid diabetes was associated with an increased risk of disease severity or death in Chinese COVID-19 patients.

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