Rapid Scaling Up of Covid-19 Diagnostic Testing in the United States - The NIH RADx Initiative

Overview

Journal N Engl J Med

Specialty General Medicine

Date 2020 Jul 25

PMID 32706958

Citations 125

Authors

Bruce J Tromberg

Tara A Schwetz

Eliseo J Perez-Stable

Richard J Hodes

Richard P Woychik

Rick A Bright

Rachael L Fleurence

Francis S Collins

Affiliations

Soon will be listed here.

Citing Articles

The Shift to Over-the-Counter Diagnostic Testing After RADx: Clinical, Regulatory, and Societal Implications.

Downing M, Broach J, Lam W, Manabe Y, Martin G, McManus D IEEE Open J Eng Med Biol. 2025; 6:237-240.

PMID: 39906263 PMC: 11793479. DOI: 10.1109/OJEMB.2024.3512189.

Extracellular RNA communication: A decade of NIH common fund support illuminates exRNA biology.

Amolegbe S, Johnston N, Ambrosi A, Ganguly A, Howcroft T, Kuo L J Extracell Vesicles. 2025; 14(1):e70016.

PMID: 39815775 PMC: 11735951. DOI: 10.1002/jev2.70016.

Regression analysis of group-tested current status data.

Li S, Hu T, Wang L, McMahan C, Tebbs J Biometrika. 2024; 111(3):1047-1061.

PMID: 39691693 PMC: 11648127. DOI: 10.1093/biomet/asae006.

Automation for lateral flow rapid tests: Protocol for an open-source fluid handler and applications to dengue and African swine fever tests.

Laurent R, Hinnant B, Talbott M, Kim K PLOS Glob Public Health. 2024; 4(11):e0002625.

PMID: 39585872 PMC: 11588214. DOI: 10.1371/journal.pgph.0002625.

Design, creation, and use of the Test Us Bank (TUB) COVID-19 sample biorepository.

Broach J, Achenbach C, Behar S, OConnor L, Tarrant S, Ferranto J BMC Infect Dis. 2024; 24(1):1282.

PMID: 39528968 PMC: 11556042. DOI: 10.1186/s12879-024-10154-0.

References

Price-Haywood E, Burton J, Fort D, Seoane L . Hospitalization and Mortality among Black Patients and White Patients with Covid-19. N Engl J Med. 2020; 382(26):2534-2543. PMC: 7269015. DOI: 10.1056/NEJMsa2011686. View

Tu Y, Jennings R, Hart B, Cangelosi G, Wood R, Wehber K . Swabs Collected by Patients or Health Care Workers for SARS-CoV-2 Testing. N Engl J Med. 2020; 383(5):494-496. PMC: 7289274. DOI: 10.1056/NEJMc2016321. View

Russell S, Alba-Patino A, Baron E, Borges M, Gonzalez-Freire M, de la Rica R . Biosensors for Managing the COVID-19 Cytokine Storm: Challenges Ahead. ACS Sens. 2020; 5(6):1506-1513. DOI: 10.1021/acssensors.0c00979. View

Gould O, Ratcliffe N, Krol E, de Lacy Costello B . Breath analysis for detection of viral infection, the current position of the field. J Breath Res. 2020; 14(4):041001. DOI: 10.1088/1752-7163/ab9c32. View

Chowkwanyun M, Reed Jr A . Racial Health Disparities and Covid-19 - Caution and Context. N Engl J Med. 2020; 383(3):201-203. DOI: 10.1056/NEJMp2012910. View

Collins F, Stoffels P . Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV): An Unprecedented Partnership for Unprecedented Times. JAMA. 2020; 323(24):2455-2457. DOI: 10.1001/jama.2020.8920. View

Sheridan C . Fast, portable tests come online to curb coronavirus pandemic. Nat Biotechnol. 2020; 38(5):515-518. DOI: 10.1038/d41587-020-00010-2. View

Yan C, Faraji F, Prajapati D, Boone C, DeConde A . Association of chemosensory dysfunction and COVID-19 in patients presenting with influenza-like symptoms. Int Forum Allergy Rhinol. 2020; 10(7):806-813. PMC: 7262089. DOI: 10.1002/alr.22579. View

Zeidel M, Kirk C, Linville-Engler B . Opening Up New Supply Chains. N Engl J Med. 2020; 382(21):e73. PMC: 7281713. DOI: 10.1056/NEJMc2009432. View

10.

Cherif A, Grobe N, Wang X, Kotanko P . Simulation of Pool Testing to Identify Patients With Coronavirus Disease 2019 Under Conditions of Limited Test Availability. JAMA Netw Open. 2020; 3(6):e2013075. PMC: 7315509. DOI: 10.1001/jamanetworkopen.2020.13075. View

11.

Sittig D, Singh H . COVID-19 and the Need for a National Health Information Technology Infrastructure. JAMA. 2020; 323(23):2373-2374. DOI: 10.1001/jama.2020.7239. View

12.

Cheng M, Papenburg J, Desjardins M, Kanjilal S, Quach C, Libman M . Diagnostic Testing for Severe Acute Respiratory Syndrome-Related Coronavirus 2: A Narrative Review. Ann Intern Med. 2020; 172(11):726-734. PMC: 7170415. DOI: 10.7326/M20-1301. View

13.

Gwinn M, MacCannell D, Armstrong G . Next-Generation Sequencing of Infectious Pathogens. JAMA. 2019; 321(9):893-894. PMC: 6682455. DOI: 10.1001/jama.2018.21669. View

14.

Sethuraman N, Jeremiah S, Ryo A . Interpreting Diagnostic Tests for SARS-CoV-2. JAMA. 2020; 323(22):2249-2251. DOI: 10.1001/jama.2020.8259. View

15.

Martinez D, Hinson J, Klein E, Irvin N, Saheed M, Page K . SARS-CoV-2 Positivity Rate for Latinos in the Baltimore-Washington, DC Region. JAMA. 2020; 324(4):392-395. PMC: 7303900. DOI: 10.1001/jama.2020.11374. View

16.

Hooper M, Napoles A, Perez-Stable E . COVID-19 and Racial/Ethnic Disparities. JAMA. 2020; 323(24):2466-2467. PMC: 9310097. DOI: 10.1001/jama.2020.8598. View

17.

Stokes E, Zambrano L, Anderson K, Marder E, Raz K, El Burai Felix S . Coronavirus Disease 2019 Case Surveillance - United States, January 22-May 30, 2020. MMWR Morb Mortal Wkly Rep. 2020; 69(24):759-765. PMC: 7302472. DOI: 10.15585/mmwr.mm6924e2. View

18.

Hogan C, Sahoo M, Pinsky B . Sample Pooling as a Strategy to Detect Community Transmission of SARS-CoV-2. JAMA. 2020; 323(19):1967-1969. PMC: 7136853. DOI: 10.1001/jama.2020.5445. View

19.

Broughton J, Deng X, Yu G, Fasching C, Servellita V, Singh J . CRISPR-Cas12-based detection of SARS-CoV-2. Nat Biotechnol. 2020; 38(7):870-874. PMC: 9107629. DOI: 10.1038/s41587-020-0513-4. View

20.

Prendergast C, Papenburg J . Rapid antigen-based testing for respiratory syncytial virus: moving diagnostics from bench to bedside?. Future Microbiol. 2013; 8(4):435-44. DOI: 10.2217/fmb.13.9. View