Carotid-femoral Pulse Wave Velocity is Significantly Increased in Newly Diagnosed Hypertensive Patients with Primary Hyperparathyroidism and Significantly Related with Serum Calcium Level

Overview

Journal J Ultrasound

Publisher Springer

Specialty Radiology

Date 2020 Jul 25

PMID 32705503

Citations 1

Authors

Mahmut Buyuksimsek

Erdinc Gulumsek

Derya Demirtas

Yahya Kemal Icen

Hilmi Erdem Sumbul

Ali Ogul

Nurettin Ay

Tayyibe Saler

Mevlut Koc

Affiliations

Soon will be listed here.

Abstract

Background: Primary hyperparathyroidism (PHP) is a rare cause of secondary hypertension (HT), but in patients with PHP, HT is very common and 20-80% of patients have HT. The aim of this study was to evaluate the change in carotid-femoral pulse wave velocity (CF-PWV) in hypertensive patients with PHP, and was to determine the clinical, laboratory, and echocardiographic parameters associated with CF-PWV.

Methods: The study included 83 newly diagnosed hypertensive patients with PHP and 83 patients with newly diagnosed essential HT without PHP. All patients underwent echocardiography and CF-PWV measurements.

Results: In patients with PHP, blood urea nitrogen, hs-CRP, uric acid, serum and urine calcium, parathyroid hormone level, CF-PWV value, LV wall thickness, LVMI, aortic and left atrium (LA) diameter, and presence of LVH and CF-PWV > 10 m/s were higher, and serum phosphorus levels were lower. Serum calcium, LA diameter, and LVMI values were closely correlated with CF-PWV. In the ROC analysis, the AUROC was calculated as 0.825 for calcium level to determine the patients with increased CF-PWV. When the serum calcium value was taken as 10 mg/dL, it was determined with CF-PWV > 10 m/s were 79.5% sensitivity and 78.2% specificity.

Conclusion: CF-PWV significantly increases in newly diagnosed hypertensive patients with PHP and significantly related to serum calcium level. To protect against target organ damage, high serum calcium levels should be monitored as well as blood pressure in hypertensive patients with PHP.

Citing Articles

Arterial Stiffness in Thyroid and Parathyroid Disease: A Review of Clinical Studies.

Grillo A, Barbato V, Antonello R, Cola M, Parati G, Salvi P J Clin Med. 2022; 11(11).

PMID: 35683533 PMC: 9180991. DOI: 10.3390/jcm11113146.

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