Picornavirus Cellular Remodeling: Doubling Down in Response to Viral-Induced Inflammation

Overview

Journal Curr Clin Microbiol Rep

Specialty Microbiology

Date 2020 Jul 25

PMID 32704466

Citations 4

Authors

Alexis Bouin

Bert L Semler

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: To highlight recent findings on how picornavirus infections of the airways and cardiac tissues impact cellular inflammation and remodeling events.

Recent Findings: Recent published work has revealed that although many picornavirus infections appear to be initially asymptomatic, there are significant disease sequelae that result from chronic or persistent infections and the long-term, pathogenic effects on host tissues.

Summary: Because many acute picornavirus infections are asymptomatic, it is difficult to diagnose these pathologies at the early stages of disease. As a result, we must rely on preventative measures (i.e., vaccination) or discover novel treatments to reverse tissue damage and remodeling in affected individuals. Both of these strategies will require a comprehensive knowledge of virus-and cell-specific replication determinants and how these processes induce pathogenic effects in infected cells and tissues.

Citing Articles

P Glutamine isosteres in the design of inhibitors of 3C/3CL protease of human viruses of the class.

Stubbing L, Hubert J, Bell-Tyrer J, Hermant Y, Yang S, McSweeney A RSC Chem Biol. 2023; 4(8):533-547.

PMID: 37547456 PMC: 10398354. DOI: 10.1039/d3cb00075c.

Enterovirus-Cardiomyocyte Interactions: Impact of Terminally Deleted Genomic RNAs on Viral and Host Functions.

Bouin A, Vu M, Al-Hakeem A, Tran G, Nguyen J, Semler B J Virol. 2022; 97(1):e0142622.

PMID: 36475766 PMC: 9888282. DOI: 10.1128/jvi.01426-22.

Persistent Enterovirus Infection: Little Deletions, Long Infections.

Chapman N Vaccines (Basel). 2022; 10(5).

PMID: 35632526 PMC: 9143164. DOI: 10.3390/vaccines10050770.

Viruses as tools in gene therapy, vaccine development, and cancer treatment.

Umair M, Akusa F, Kashif H, Seerat-E-Fatima , Butt F, Azhar M Arch Virol. 2022; 167(6):1387-1404.

PMID: 35462594 PMC: 9035288. DOI: 10.1007/s00705-022-05432-8.

References

Wang J, Ptacek J, Kirkegaard K, Bullitt E . Double-membraned liposomes sculpted by poliovirus 3AB protein. J Biol Chem. 2013; 288(38):27287-27298. PMC: 3779724. DOI: 10.1074/jbc.M113.498899. View

den Boon J, Ahlquist P . Organelle-like membrane compartmentalization of positive-strand RNA virus replication factories. Annu Rev Microbiol. 2010; 64:241-56. DOI: 10.1146/annurev.micro.112408.134012. View

Misbahuddin M Rafeeq , Murad H . Cystic fibrosis: current therapeutic targets and future approaches. J Transl Med. 2017; 15(1):84. PMC: 5408469. DOI: 10.1186/s12967-017-1193-9. View

Doenst T, Nguyen T, Abel E . Cardiac metabolism in heart failure: implications beyond ATP production. Circ Res. 2013; 113(6):709-24. PMC: 3896379. DOI: 10.1161/CIRCRESAHA.113.300376. View

Etemadi M, Ling K, Zainal Abidin S, Chee H, Sekawi Z . Gene expression patterns induced at different stages of rhinovirus infection in human alveolar epithelial cells. PLoS One. 2017; 12(5):e0176947. PMC: 5448745. DOI: 10.1371/journal.pone.0176947. View

Ramirez I, Caverly L, Caverly L, Kalikin L, Goldsmith A, Lewis T . Differential responses to rhinovirus- and influenza-associated pulmonary exacerbations in patients with cystic fibrosis. Ann Am Thorac Soc. 2014; 11(4):554-61. PMC: 4225796. DOI: 10.1513/AnnalsATS.201310-346OC. View

Tracy S, Smithee S, Alhazmi A, Chapman N . Coxsackievirus can persist in murine pancreas by deletion of 5' terminal genomic sequences. J Med Virol. 2014; 87(2):240-7. DOI: 10.1002/jmv.24039. View

Knowlton K . Dilated Cardiomyopathy. Circulation. 2019; 139(20):2339-2341. DOI: 10.1161/CIRCULATIONAHA.119.040037. View

Triantafilou K, Orthopoulos G, Vakakis E, Abd Elrahman Ahmed M, Golenbock D, Lepper P . Human cardiac inflammatory responses triggered by Coxsackie B viruses are mainly Toll-like receptor (TLR) 8-dependent. Cell Microbiol. 2005; 7(8):1117-26. DOI: 10.1111/j.1462-5822.2005.00537.x. View

10.

Lafferty E, Wiltshire S, Angers I, Vidal S, Qureshi S . Unc93b1 -Dependent Endosomal Toll-Like Receptor Signaling Regulates Inflammation and Mortality during Coxsackievirus B3 Infection. J Innate Immun. 2015; 7(3):315-30. PMC: 6738833. DOI: 10.1159/000369342. View

11.

Barnabei M, Sjaastad F, Townsend D, Bedada F, Metzger J . Severe dystrophic cardiomyopathy caused by the enteroviral protease 2A-mediated C-terminal dystrophin cleavage fragment. Sci Transl Med. 2015; 7(294):294ra106. DOI: 10.1126/scitranslmed.aaa4804. View

12.

Rowan N, Wang E, Kanaan A, Sahu N, Williams J, Phillips C . Respiratory viral detection in the paranasal sinuses of patients with cystic fibrosis. Am J Rhinol Allergy. 2017; 31(2):105-108. DOI: 10.2500/ajra.2017.31.4422. View

13.

Rivadeneyra L, Charo N, Kviatcovsky D, de la Barrera S, Gomez R, Schattner M . Role of neutrophils in CVB3 infection and viral myocarditis. J Mol Cell Cardiol. 2018; 125:149-161. DOI: 10.1016/j.yjmcc.2018.08.029. View

14.

Bozym R, Patel K, White C, Cheung K, Bergelson J, Morosky S . Calcium signals and calpain-dependent necrosis are essential for release of coxsackievirus B from polarized intestinal epithelial cells. Mol Biol Cell. 2011; 22(17):3010-21. PMC: 3164450. DOI: 10.1091/mbc.E11-02-0094. View

15.

Remels A, Derks W, Cillero-Pastor B, Verhees K, Kelders M, Heggermont W . NF-κB-mediated metabolic remodelling in the inflamed heart in acute viral myocarditis. Biochim Biophys Acta Mol Basis Dis. 2018; 1864(8):2579-2589. DOI: 10.1016/j.bbadis.2018.04.022. View

16.

Muller I, Vogl T, Pappritz K, Miteva K, Savvatis K, Rohde D . Pathogenic Role of the Damage-Associated Molecular Patterns S100A8 and S100A9 in Coxsackievirus B3-Induced Myocarditis. Circ Heart Fail. 2017; 10(11). DOI: 10.1161/CIRCHEARTFAILURE.117.004125. View

17.

Guo Y, Wu W, Cen Z, Li X, Kong Q, Zhou Q . IL-22-producing Th22 cells play a protective role in CVB3-induced chronic myocarditis and dilated cardiomyopathy by inhibiting myocardial fibrosis. Virol J. 2014; 11:230. PMC: 4304148. DOI: 10.1186/s12985-014-0230-z. View

18.

Kawai E, Sato F, Omura S, Martinez N, Reddy P, Taniguchi M . Organ-specific protective role of NKT cells in virus-induced inflammatory demyelination and myocarditis depends on mouse strain. J Neuroimmunol. 2014; 278:174-84. PMC: 4297752. DOI: 10.1016/j.jneuroim.2014.11.003. View

19.

Corona A, Mohamud Y, Jackson W, Luo H . Oh, SNAP! How enteroviruses redirect autophagic traffic away from degradation. Autophagy. 2018; 14(8):1469-1471. PMC: 6103677. DOI: 10.1080/15548627.2018.1480849. View

20.

Dunne J, Richardson S, Atkinson M, Craig M, Dahl-Jorgensen K, Flodstrom-Tullberg M . Large enteroviral vaccination studies to prevent type 1 diabetes should be well founded and rely on scientific evidence. Reply to Skog O, Klingel K, Roivainen M et al [letter]. Diabetologia. 2019; 62(6):1100-1103. DOI: 10.1007/s00125-019-4873-6. View