Association Between Visceral Fat and Bone Mineral Density in Both Male and Female Patients with Adult Growth Hormone Deficiency

Overview

Journal Biochem Res Int

Publisher Wiley

Specialty Biochemistry

Date 2020 Jul 23

PMID 32695511

Citations 1

Authors

Linman Li

Li Zhong

Xiaoya Zheng

Wenyi You

Yunting Wang

Jihui Yu

Xun Wu

Wei Ren

Gangyi Yang

Affiliations

Soon will be listed here.

Abstract

Aim: Adult growth hormone deficiency (AGHD) is associated with an increased risk of fractures. The interactions between various body composition and bone are known to be complex in nature. However, very few studies have examined this crosstalk in AGHD. In this study, we sought to investigate the relationship between various parameters of body composition and bone mineral density (BMD) as well as determine the role of visceral fat in determining the bone mass in patients with AGHD.

Methods: We conducted a cross-sectional study on 57 patients with AGHD. Anthropometry, biochemistry, and analysis of body composition and BMD were performed according to standard protocols. Male and female patients were classified into those with osteoporosis and those without osteoporosis (normal subjects and patients with osteopenia). Further, we analyzed the correlation between the BMD and measurements obtained for various body composition parameters in male and female AGHD patients.

Results: Our findings indicated that among female AGHD patients, those with osteoporosis had a significantly higher levels of fat mass (FM) and visceral adipose tissue mass (VATM) (both, < 0.05) than those without osteoporosis. Further, Pearson correlation analysis showed that the values of age, body mass index (BMI), FM, and VATM correlated negatively with BMD in women with AGHD (all < 0.05); however, this association was not noted in men. After adjusting for the other covariates, VATM was found to be independently correlated with the BMD in female patients with AGHD.

Conclusions: A close correlation was noted between VATM and BMD in female patients with AGHD.

Citing Articles

Association between visceral fat and bone mineral density in perimenopausal women.

Tang X, Tang L, Li X, Cao J, Wang H, Liu S PeerJ. 2025; 13:e18957.

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Skeletal disorders associated with the growth hormone-insulin-like growth factor 1 axis.

Mazziotti G, Lania A, Canalis E Nat Rev Endocrinol. 2022; 18(6):353-365.

PMID: 35288658 DOI: 10.1038/s41574-022-00649-8.

References

Zhao L, Jiang H, Papasian C, Maulik D, Drees B, Hamilton J . Correlation of obesity and osteoporosis: effect of fat mass on the determination of osteoporosis. J Bone Miner Res. 2007; 23(1):17-29. PMC: 2663586. DOI: 10.1359/jbmr.070813. View

Takeda S . [Effect of obesity on bone metabolism]. Clin Calcium. 2008; 18(5):632-7. DOI: CliCa0805632637. View

Gazzaruso C, Gola M, Karamouzis I, Giubbini R, Giustina A . Cardiovascular risk in adult patients with growth hormone (GH) deficiency and following substitution with GH--an update. J Clin Endocrinol Metab. 2013; 99(1):18-29. DOI: 10.1210/jc.2013-2394. View

Pop L, Sukumar D, Schneider S, Schlussel Y, Stahl T, Gordon C . Three doses of vitamin D, bone mineral density, and geometry in older women during modest weight control in a 1-year randomized controlled trial. Osteoporos Int. 2016; 28(1):377-388. DOI: 10.1007/s00198-016-3735-z. View

Kumar A, Sharma A, Mittal S, Kumar G . The Relationship Between Body Mass Index and Bone Mineral Density in Premenopausal and Postmenopausal North Indian Women. J Obstet Gynaecol India. 2016; 66(1):52-6. PMC: 4755946. DOI: 10.1007/s13224-014-0629-x. View

Kirchengast S, Peterson B, Hauser G, Knogler W . Body composition characteristics are associated with the bone density of the proximal femur end in middle- and old-aged women and men. Maturitas. 2001; 39(2):133-45. DOI: 10.1016/s0378-5122(01)00205-5. View

Mohd Zain N, Seriramulu V, Chelliah K . Bone Mineral Density and Breast Cancer Risk Factors among Premenopausal and Postmenopausal Women A Systematic Review. Asian Pac J Cancer Prev. 2016; 17(7):3229-34. View

Li L, Ren W, Li J, Liu J, Wang L, Zheng X . Increase in serum pregnancy-associated plasma protein-A is correlated with increase in cardiovascular risk factors in adult patients with growth hormone deficiency. Endocrine. 2012; 42(2):375-81. DOI: 10.1007/s12020-012-9697-9. View

Kassem M, Blum W, Ristelli J, Mosekilde L, Eriksen E . Growth hormone stimulates proliferation and differentiation of normal human osteoblast-like cells in vitro. Calcif Tissue Int. 1993; 52(3):222-6. DOI: 10.1007/BF00298723. View

10.

Yakar S, Rosen C, Beamer W, Ackert-Bicknell C, Wu Y, Liu J . Circulating levels of IGF-1 directly regulate bone growth and density. J Clin Invest. 2002; 110(6):771-81. PMC: 151128. DOI: 10.1172/JCI15463. View

11.

. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Report of a WHO Study Group. World Health Organ Tech Rep Ser. 1994; 843:1-129. View

12.

Kang D, Guo L, Guo T, Wang Y, Liu T, Feng X . Association of body composition with bone mineral density in northern Chinese men by different criteria for obesity. J Endocrinol Invest. 2014; 38(3):323-31. DOI: 10.1007/s40618-014-0167-5. View

13.

Taes Y, Lapauw B, Vanbillemont G, Bogaert V, De Bacquer D, Zmierczak H . Fat mass is negatively associated with cortical bone size in young healthy male siblings. J Clin Endocrinol Metab. 2009; 94(7):2325-31. DOI: 10.1210/jc.2008-2501. View

14.

Arimatsu M, Kitano T, Kitano N, Futatsuka M . Correlation between bone mineral density and body composition in Japanese females aged 18-40 years with low forearm bone mineral density. Environ Health Prev Med. 2009; 14(1):46-51. PMC: 2684765. DOI: 10.1007/s12199-008-0056-7. View

15.

Wang Y, Zheng X, Xie X, Qian W, Zhang L, Ren W . CORRELATION OF INCREASED SERUM ADIPSIN WITH INCREASED CARDIOVASCULAR RISKS IN ADULT PATIENTS WITH GROWTH HORMONE DEFICIENCY. Endocr Pract. 2019; 25(5):446-453. DOI: 10.4158/EP-2018-0541. View

16.

Kim Y, Kim S, Kim S, Yoo J, Choe E, Won Y . Variations in fat mass contribution to bone mineral density by gender, age, and body mass index: the Korea National Health and Nutrition Examination Survey (KNHANES) 2008-2011. Osteoporos Int. 2016; 27(8):2543-54. DOI: 10.1007/s00198-016-3566-y. View

17.

Sambrook P, Cooper C . Osteoporosis. Lancet. 2006; 367(9527):2010-8. DOI: 10.1016/S0140-6736(06)68891-0. View

18.

Yakar S, Werner H, Rosen C . Insulin-like growth factors: actions on the skeleton. J Mol Endocrinol. 2018; 61(1):T115-T137. PMC: 5966339. DOI: 10.1530/JME-17-0298. View

19.

Marwaha R, Garg M, Tandon N, Mehan N, Sastry A, Bhadra K . Relationship of body fat and its distribution with bone mineral density in Indian population. J Clin Densitom. 2013; 16(3):353-359. DOI: 10.1016/j.jocd.2012.08.074. View

20.

Ng A, Melton 3rd L, Atkinson E, Achenbach S, Holets M, Peterson J . Relationship of adiposity to bone volumetric density and microstructure in men and women across the adult lifespan. Bone. 2013; 55(1):119-25. PMC: 3650114. DOI: 10.1016/j.bone.2013.02.006. View