Effect of Exercise on Quality of Life in Parkinson's Disease: A Systematic Review and Meta-Analysis

Overview

Journal Parkinsons Dis

Publisher Wiley

Date 2020 Jul 23

PMID 32695306

Citations 24

Authors

Kui Chen

Yan Tan

You Lu

Jiayan Wu

Xueyuan Liu

Yanxin Zhao

Affiliations

Soon will be listed here.

Abstract

Background: Exercise has an integral impact on the physical and mental wellbeing of patients with Parkinson's disease (PD), yet no comprehensive and quantitative analysis has been conducted on the effect of exercise on quality of life (QoL) in these patients. This study aimed to evaluate the effect of exercise on overall QoL and different domains of QoL in people with PD, as well as investigating the influence of factors such as the exercise type and intervention period.

Methods: Databases, such as PubMed, Embase, and Cochrane Central Register of Controlled Trials, were searched since inception to August 14, 2018 to identify randomized controlled trials that compare the effect of exercise versus no intervention on QoL in PD patients. Following the subgroup analysis, heterogeneity was further explored. The quality of eligible studies was assessed according to PRISMA guidelines.

Results: 20 studies were included with 1,143 participants in total. A meta-analysis showed a significant improvement in QoL after exercise intervention in PD patients (SMD = -0.24, 95% CI = -0.36 to -0.12, < 0.001). A subgroup analysis of exercise types revealed significant QoL improvement with aerobic exercise, martial arts, and dance, but not anaerobic exercise and combined exercise. Interventions lasting 12 weeks or longer improved QoL significantly.

Conclusions: Exercise interventions, especially aerobic exercise, dance, and Tai Chi, significantly improve QoL in PD patients. At least 12 weeks of exercise is needed to bring about significant benefits.

Citing Articles

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Quality assessment and umbrella review of systematic reviews about dance for people with Parkinson's disease.

Pinto C, Simon Myra R, Pinho A, Pereira F, Orgs G, Pagnussat A PLoS One. 2024; 19(12):e0311003.

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Exercise Habits in People with Parkinson's: A Multinational Survey.

Jagota P, Phutrakool P, Kamble N, Huyen Thi Dang T, Aldaajani Z, Hatano T Mov Disord Clin Pract. 2024; 11(11):1396-1409.

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References

Tollar J, Nagy F, Kovacs N, Hortobagyi T . A High-Intensity Multicomponent Agility Intervention Improves Parkinson Patients' Clinical and Motor Symptoms. Arch Phys Med Rehabil. 2018; 99(12):2478-2484.e1. DOI: 10.1016/j.apmr.2018.05.007. View

Winward C, Sackley C, Meek C, Izadi H, Barker K, Wade D . Weekly exercise does not improve fatigue levels in Parkinson's disease. Mov Disord. 2011; 27(1):143-6. DOI: 10.1002/mds.23966. View

Ellis T, de Goede C, Feldman R, Wolters E, Kwakkel G, Wagenaar R . Efficacy of a physical therapy program in patients with Parkinson's disease: a randomized controlled trial. Arch Phys Med Rehabil. 2005; 86(4):626-32. DOI: 10.1016/j.apmr.2004.08.008. View

Cheon S, Chae B, Sung H, Lee G, Kim J . The Efficacy of Exercise Programs for Parkinson's Disease: Tai Chi versus Combined Exercise. J Clin Neurol. 2013; 9(4):237-43. PMC: 3840134. DOI: 10.3988/jcn.2013.9.4.237. View

Brooks R . EuroQol: the current state of play. Health Policy. 1996; 37(1):53-72. DOI: 10.1016/0168-8510(96)00822-6. View

Liberati A, Altman D, Tetzlaff J, Mulrow C, Gotzsche P, Ioannidis J . The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol. 2009; 62(10):e1-34. DOI: 10.1016/j.jclinepi.2009.06.006. View

Tomlinson C, Patel S, Meek C, Herd C, Clarke C, Stowe R . Physiotherapy intervention in Parkinson's disease: systematic review and meta-analysis. BMJ. 2012; 345:e5004. PMC: 3412755. DOI: 10.1136/bmj.e5004. View

Allen N, Canning C, Sherrington C, Lord S, Latt M, Close J . The effects of an exercise program on fall risk factors in people with Parkinson's disease: a randomized controlled trial. Mov Disord. 2010; 25(9):1217-25. DOI: 10.1002/mds.23082. View

Peek A, Stevens M . Resistance training for people with Parkinson's disease (PEDro synthesis). Br J Sports Med. 2016; 50(18):1158. DOI: 10.1136/bjsports-2016-096311. View

10.

Kwok J, Kwan J, Auyeung M, Mok V, Lau C, Choi K . Effects of Mindfulness Yoga vs Stretching and Resistance Training Exercises on Anxiety and Depression for People With Parkinson Disease: A Randomized Clinical Trial. JAMA Neurol. 2019; 76(7):755-763. PMC: 6583059. DOI: 10.1001/jamaneurol.2019.0534. View

11.

. Development of the World Health Organization WHOQOL-BREF quality of life assessment. The WHOQOL Group. Psychol Med. 1998; 28(3):551-8. DOI: 10.1017/s0033291798006667. View

12.

Ware Jr J, Kosinski M, Keller S . A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. Med Care. 1996; 34(3):220-33. DOI: 10.1097/00005650-199603000-00003. View

13.

Li F, Harmer P, Fitzgerald K, Eckstrom E, Stock R, Galver J . Tai chi and postural stability in patients with Parkinson's disease. N Engl J Med. 2012; 366(6):511-9. PMC: 3285459. DOI: 10.1056/NEJMoa1107911. View

14.

Cholewa J, Boczarska-Jedynak M, Opala G . Influence of physiotherapy on severity of motor symptoms and quality of life in patients with Parkinson disease. Neurol Neurochir Pol. 2013; 47(3):256-62. DOI: 10.5114/ninp.2013.35774. View

15.

Altmann L, Stegemoller E, Hazamy A, Wilson J, Bowers D, Okun M . Aerobic Exercise Improves Mood, Cognition, and Language Function in Parkinson's Disease: Results of a Controlled Study. J Int Neuropsychol Soc. 2016; 22(9):878-889. DOI: 10.1017/S135561771600076X. View

16.

Morris M, Taylor N, Watts J, Evans A, Horne M, Kempster P . A home program of strength training, movement strategy training and education did not prevent falls in people with Parkinson's disease: a randomised trial. J Physiother. 2017; 63(2):94-100. DOI: 10.1016/j.jphys.2017.02.015. View

17.

Ni M, Signorile J, Balachandran A, Potiaumpai M . Power training induced change in bradykinesia and muscle power in Parkinson's disease. Parkinsonism Relat Disord. 2015; 23:37-44. DOI: 10.1016/j.parkreldis.2015.11.028. View

18.

Rascol O, Payoux P, Ferreira J, Brefel-Courbon C . The management of patients with early Parkinson's disease. Parkinsonism Relat Disord. 2002; 9(1):61-7. DOI: 10.1016/s1353-8020(02)00045-7. View

19.

McKee K, Hackney M . The effects of adapted tango on spatial cognition and disease severity in Parkinson's disease. J Mot Behav. 2013; 45(6):519-29. PMC: 3864026. DOI: 10.1080/00222895.2013.834288. View

20.

Cruise K, Bucks R, Loftus A, Newton R, Pegoraro R, Thomas M . Exercise and Parkinson's: benefits for cognition and quality of life. Acta Neurol Scand. 2010; 123(1):13-9. DOI: 10.1111/j.1600-0404.2010.01338.x. View