Resistin Family Proteins in Pulmonary Diseases

Overview

Journal Am J Physiol Lung Cell Mol Physiol

Publisher American Physiological Society

Specialties Cell Biology
Molecular Biology
Physiology
Pulmonary Medicine

Date 2020 Jul 22

PMID 32692581

Citations 19

Authors

Qing Lin

Roger A Johns

Affiliations

Soon will be listed here.

Abstract

The family of resistin-like molecules (RELMs) consists of four members in rodents (RELMα/FIZZ1/HIMF, RELMβ/FIZZ2, Resistin/FIZZ3, and RELMγ/FIZZ4) and two members in humans (Resistin and RELMβ), all of which exhibit inflammation-regulating, chemokine, and growth factor properties. The importance of these cytokines in many aspects of physiology and pathophysiology, especially in cardiothoracic diseases, is rapidly evolving in the literature. In this review article, we attempt to summarize the contribution of RELM signaling to the initiation and progression of lung diseases, such as pulmonary hypertension, asthma/allergic airway inflammation, chronic obstructive pulmonary disease, fibrosis, cancers, infection, and other acute lung injuries. The potential of RELMs to be used as biomarkers or risk predictors of these diseases also will be discussed. Better understanding of RELM signaling in the pathogenesis of pulmonary diseases may offer novel targets or approaches for the development of therapeutics to treat or prevent a variety of inflammation, tissue remodeling, and fibrosis-related disorders in respiratory, cardiovascular, and other systems.

Citing Articles

Resistin predicts disease severity and survival in patients with pulmonary arterial hypertension.

Gao L, Skinner J, Nath T, Lin Q, Griffiths M, Damico R Respir Res. 2024; 25(1):235.

PMID: 38844967 PMC: 11154998. DOI: 10.1186/s12931-024-02861-8.

Regulation of cardiac fibrosis in mice with TAC/DOCA-induced HFpEF by resistin-like molecule gamma and adenylate cyclase 1.

Liu D, Zeng F, Chen Z, Qin Z, Liu Z FEBS Open Bio. 2024; 14(7):1101-1115.

PMID: 38710658 PMC: 11216931. DOI: 10.1002/2211-5463.13813.

The Role of Peptides in Asthma-Obesity Phenotype.

Russjan E Int J Mol Sci. 2024; 25(6).

PMID: 38542187 PMC: 10970696. DOI: 10.3390/ijms25063213.

Adipokines in pulmonary hypertension: angels or demons?.

Jia Q, Ouyang Y, Yang Y, Yao S, Chen X, Hu Z Heliyon. 2023; 9(11):e22482.

PMID: 38074873 PMC: 10700708. DOI: 10.1016/j.heliyon.2023.e22482.

Linking Adiposity to Interstitial Lung Disease: The Role of the Dysfunctional Adipocyte and Inflammation.

Macklin M, Thompson C, Kawano-Dourado L, Bauer Ventura I, Weschenfelder C, Trostchansky A Cells. 2023; 12(18).

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References

Hoeve M, Mylonas K, Fairlie-Clarke K, Mahajan S, Allen J, Graham A . Plasmodium chabaudi limits early Nippostrongylus brasiliensis-induced pulmonary immune activation and Th2 polarization in co-infected mice. BMC Immunol. 2009; 10:60. PMC: 3224723. DOI: 10.1186/1471-2172-10-60. View

Kolosova I, Angelini D, Fan C, Skinner J, Cheadle C, Johns R . Resistin-like molecule α stimulates proliferation of mesenchymal stem cells while maintaining their multipotency. Stem Cells Dev. 2012; 22(2):239-47. PMC: 3545352. DOI: 10.1089/scd.2012.0192. View

Mendivil C, Koziel H, Brain J . Metabolic hormones, apolipoproteins, adipokines, and cytokines in the alveolar lining fluid of healthy adults: compartmentalization and physiological correlates. PLoS One. 2015; 10(4):e0123344. PMC: 4388476. DOI: 10.1371/journal.pone.0123344. View

Nohira T, Nagao K, Kameyama K, Nakai H, Fukumine N, Okabe K . Identification of an alternative splicing transcript for the resistin gene and distribution of its mRNA in human tissue. Eur J Endocrinol. 2004; 151(1):151-4. DOI: 10.1530/eje.0.1510151. View

Fan C, Meuchel L, Su Q, Angelini D, Zhang A, Cheadle C . Resistin-Like Molecule α in Allergen-Induced Pulmonary Vascular Remodeling. Am J Respir Cell Mol Biol. 2015; 53(3):303-13. PMC: 4566066. DOI: 10.1165/rcmb.2014-0322OC. View

Liu T, Baek H, Yu H, Lee H, Park B, Ullenbruch M . FIZZ2/RELM-β induction and role in pulmonary fibrosis. J Immunol. 2011; 187(1):450-61. PMC: 4030639. DOI: 10.4049/jimmunol.1000964. View

Tsai C, Tsai H, Huang H, Hung C, Hsu C, Fong Y . Resistin promotes tumor metastasis by down-regulation of miR-519d through the AMPK/p38 signaling pathway in human chondrosarcoma cells. Oncotarget. 2014; 6(1):258-70. PMC: 4381593. DOI: 10.18632/oncotarget.2724. View

Nair M, Du Y, Perrigoue J, Zaph C, Taylor J, Goldschmidt M . Alternatively activated macrophage-derived RELM-{alpha} is a negative regulator of type 2 inflammation in the lung. J Exp Med. 2009; 206(4):937-52. PMC: 2715126. DOI: 10.1084/jem.20082048. View

Madala S, Edukulla R, Davis K, Schmidt S, Davidson C, Kitzmiller J . Resistin-like molecule α1 (Fizz1) recruits lung dendritic cells without causing pulmonary fibrosis. Respir Res. 2012; 13:51. PMC: 3485088. DOI: 10.1186/1465-9921-13-51. View

10.

Said S, Hamidi S, Gonzalez Bosc L . Asthma and pulmonary arterial hypertension: do they share a key mechanism of pathogenesis?. Eur Respir J. 2010; 35(4):730-4. PMC: 2963099. DOI: 10.1183/09031936.00097109. View

11.

Swain S, Han S, Harmsen A, Shampeny K, Harmsen A . Pulmonary hypertension can be a sequela of prior Pneumocystis pneumonia. Am J Pathol. 2007; 171(3):790-9. PMC: 1959506. DOI: 10.2353/ajpath.2007.070178. View

12.

Mavi P, Niranjan R, Dutt P, Zaidi A, Shukla J, Korfhagen T . Allergen-induced resistin-like molecule-α promotes esophageal epithelial cell hyperplasia in eosinophilic esophagitis. Am J Physiol Gastrointest Liver Physiol. 2014; 307(5):G499-507. PMC: 4154121. DOI: 10.1152/ajpgi.00141.2014. View

13.

Lederer D, Kawut S, Wickersham N, Winterbottom C, Bhorade S, Palmer S . Obesity and primary graft dysfunction after lung transplantation: the Lung Transplant Outcomes Group Obesity Study. Am J Respir Crit Care Med. 2011; 184(9):1055-61. PMC: 3208644. DOI: 10.1164/rccm.201104-0728OC. View

14.

Al-Biltagi M, Tolba O, Mawlana W, Abd El Hamed A, Ghazy M . Resistin and right ventricular function in children with recently diagnosed type-1 diabetes mellitus: a case control study. J Pediatr Endocrinol Metab. 2015; 28(3-4):299-308. DOI: 10.1515/jpem-2014-0264. View

15.

Banerjee R, Lazar M . Dimerization of resistin and resistin-like molecules is determined by a single cysteine. J Biol Chem. 2001; 276(28):25970-3. DOI: 10.1074/jbc.M103109200. View

16.

Gerstmayer B, Kusters D, Gebel S, Muller T, Van Miert E, Hofmann K . Identification of RELMgamma, a novel resistin-like molecule with a distinct expression pattern. Genomics. 2003; 81(6):588-95. DOI: 10.1016/s0888-7543(03)00070-3. View

17.

Chung M, Liu T, Ullenbruch M, Phan S . Antiapoptotic effect of found in inflammatory zone (FIZZ)1 on mouse lung fibroblasts. J Pathol. 2007; 212(2):180-7. DOI: 10.1002/path.2161. View

18.

Gong W, Liu J, Yin J, Cui J, Xiao D, Zhuo W . Resistin facilitates metastasis of lung adenocarcinoma through the TLR4/Src/EGFR/PI3K/NF-κB pathway. Cancer Sci. 2018; 109(8):2391-2400. PMC: 6113506. DOI: 10.1111/cas.13704. View

19.

Park H, Kwak M, Kim H, Ahima R . Linking resistin, inflammation, and cardiometabolic diseases. Korean J Intern Med. 2017; 32(2):239-247. PMC: 5339472. DOI: 10.3904/kjim.2016.229. View

20.

Pine G, Batugedara H, Nair M . Here, there and everywhere: Resistin-like molecules in infection, inflammation, and metabolic disorders. Cytokine. 2018; 110:442-451. PMC: 6103837. DOI: 10.1016/j.cyto.2018.05.014. View