The Molecular Mechanisms Associated with the Physiological Responses to Inflammation and Oxidative Stress in Cardiovascular Diseases

Overview

Journal Biophys Rev

Publisher Springer

Specialty Biophysics

Date 2020 Jul 22

PMID 32691301

Citations 27

Authors

Saltanat Zhazykbayeva

Steffen Pabel

Andreas Mugge

Samuel Sossalla

Nazha Hamdani

Affiliations

Soon will be listed here.

Abstract

The complex physiological signal transduction networks that respond to the dual challenges of inflammatory and oxidative stress are major factors that promote the development of cardiovascular pathologies. These signaling networks contribute to the development of age-related diseases, suggesting crosstalk between the development of aging and cardiovascular disease. Inhibition and/or attenuation of these signaling networks also delays the onset of disease. Therefore, a concept of targeting the signaling networks that are involved in inflammation and oxidative stress may represent a novel treatment paradigm for many types of heart disease. In this review, we discuss the molecular mechanisms associated with the physiological responses to inflammation and oxidative stress especially in heart failure with preserved ejection fraction and emphasize the nature of the crosstalk of these signaling processes as well as possible therapeutic implications for cardiovascular medicine.

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