The Specific Pattern of Retinal Nerve Fiber Layer Thinning in Parkinson's Disease: a Systematic Review and Meta-analysis

Overview

Journal J Neurol

Specialty Neurology

Date 2020 Jul 22

PMID 32691237

Citations 12

Authors

Lele Huang

Chen Wang

Wanting Wang

Yujie Wang

Ruijun Zhang

Affiliations

Soon will be listed here.

Abstract

Background And Purpose: The peripapillar nerve fiber layer (pRNFL) thinning in different retinal quadrants or sectors remains controversy. We conducted a systematic review and meta-analysis on the pattern of pRNFL thinning in Parkinson's disease (PD) patients to provide a biomarker for PD differential diagnosis.

Methods: We systematically searched PubMed and EMBASE to identify studies comparing pRNFL thickness in PD patients and health controls using spectral domain-optical coherence tomography from inception to April 25, 2020. Random effects mode was used to pool mean difference (μm) of the average thickness of pRNFL and the thickness of pRNFL in four quadrants (superior, inferior, nasal and temporal) and in the subdivisions of superior (superonasal and superotemporal sectors) and inferior quadrants (inferonasal and inferotemporal sectors) between PD patients and health controls.

Results: We included 32 studies (33 sets of data) enrolling 2126 PD eyes and 2318 health control eyes. Between the eyes of PD patients and that of health controls, the pooled mean difference (μm) of average pRNFL was - 4.85 (95% CI [- 6.12, - 3.58]); the pooled mean difference (μm) of four quadrants were - 2.30 (95% CI [- 3.32, - 1.28], nasal), - 2.74 (95% CI [- 4.34, - 1.14], temporal), - 5.24 (95% CI [- 7.04, - 3.43], superior) and - 7.29 (95% CI [- 9.23, - 5.34], inferior); those of four sectors were - 5.16 (95% CI [- 7.70, - 2.62], superotemporal), - 3.55 (95% CI [- 5.87, - 1.23], superonasal), - 9.19 (95% [- 13.27, - 5.12], inferotemporal) and - 7.62 (95% CI [- 11.84, - 3.40], inferonasal).

Conclusion: In PD patients, pRNFL thinning followed a specific pattern with inferotemporal thinning most and nasal quadrant thinning least.

Citing Articles

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Connecting the Dots: Exploring the Relationship between Optical Coherence Tomography and Tc-TRODAT-1 SPECT Parameters in Parkinson's Disease.

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Tran K, Lee P, Finkelstein D, McKendrick A, Nguyen B, Bui B J Parkinsons Dis. 2024; 14(1):167-180.

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