Pathogenesis, Assessments, and Management of Chemotherapy-Related Cognitive Impairment (CRCI): An Updated Literature Review

Overview

Journal J Oncol

Specialty Oncology

Date 2020 Jul 21

PMID 32684930

Citations 21

Authors

Longqin Lv

Shanping Mao

Huimin Dong

Pan Hu

Ruochen Dong

Affiliations

Soon will be listed here.

Abstract

There are various cancer treatments at present, and chemotherapy is one of the main methods. Chemotherapy-related cognitive impairment (CRCI), as one of the side effects of chemotherapy, has gradually attracted the attention of more and more researchers. CRCI has been verified by subjective reports and objective neuropsychological tests so far. But oncologists' understanding of it and its treatments are still incomplete. In this review, we mainly give a comprehensive overview of the mechanism of CRCI, then describe a variety of evaluation methods, and finally summarize the treatment approaches under current medical conditions and compare it with an excellent article published in 2015 with the aim of providing directions for future research and better understanding of CRCI for clinicians.

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References

Reinvang I, Espeseth T, Westlye L . APOE-related biomarker profiles in non-pathological aging and early phases of Alzheimer's disease. Neurosci Biobehav Rev. 2013; 37(8):1322-35. DOI: 10.1016/j.neubiorev.2013.05.006. View

Cheng H, Li W, Gan C, Zhang B, Jia Q, Wang K . The COMT (rs165599) gene polymorphism contributes to chemotherapy-induced cognitive impairment in breast cancer patients. Am J Transl Res. 2016; 8(11):5087-5097. PMC: 5126352. View

Oh B, Butow P, Mullan B, Clarke S, Beale P, Pavlakis N . Effect of medical Qigong on cognitive function, quality of life, and a biomarker of inflammation in cancer patients: a randomized controlled trial. Support Care Cancer. 2011; 20(6):1235-42. DOI: 10.1007/s00520-011-1209-6. View

Lower E, Fleishman S, Cooper A, Zeldis J, Faleck H, Yu Z . Efficacy of dexmethylphenidate for the treatment of fatigue after cancer chemotherapy: a randomized clinical trial. J Pain Symptom Manage. 2009; 38(5):650-62. DOI: 10.1016/j.jpainsymman.2009.03.011. View

Konat G, Kraszpulski M, James I, Zhang H, Abraham J . Cognitive dysfunction induced by chronic administration of common cancer chemotherapeutics in rats. Metab Brain Dis. 2008; 23(3):325-33. DOI: 10.1007/s11011-008-9100-y. View

Koppelmans V, de Ruiter M, van der Lijn F, Boogerd W, Seynaeve C, van der Lugt A . Global and focal brain volume in long-term breast cancer survivors exposed to adjuvant chemotherapy. Breast Cancer Res Treat. 2011; 132(3):1099-106. DOI: 10.1007/s10549-011-1888-1. View

Attia A, Rapp S, Case L, DAgostino R, Lesser G, Naughton M . Phase II study of Ginkgo biloba in irradiated brain tumor patients: effect on cognitive function, quality of life, and mood. J Neurooncol. 2012; 109(2):357-63. PMC: 3752650. DOI: 10.1007/s11060-012-0901-9. View

Deprez S, Amant F, Smeets A, Peeters R, Leemans A, Van Hecke W . Longitudinal assessment of chemotherapy-induced structural changes in cerebral white matter and its correlation with impaired cognitive functioning. J Clin Oncol. 2011; 30(3):274-81. DOI: 10.1200/JCO.2011.36.8571. View

Boele F, Schilder C, de Roode M, Deijen J, Schagen S . Cognitive functioning during long-term tamoxifen treatment in postmenopausal women with breast cancer. Menopause. 2014; 22(1):17-25. DOI: 10.1097/GME.0000000000000271. View

10.

Kesler S, Wefel J, Hosseini S, Cheung M, Watson C, Hoeft F . Default mode network connectivity distinguishes chemotherapy-treated breast cancer survivors from controls. Proc Natl Acad Sci U S A. 2013; 110(28):11600-5. PMC: 3710809. DOI: 10.1073/pnas.1214551110. View

11.

Mathan S, Smart A, Ververs T, Feuerstein M . Towards an index of cognitive efficacy EEG-based estimation of cognitive load among individuals experiencing cancer-related cognitive decline. Annu Int Conf IEEE Eng Med Biol Soc. 2010; 2010:6595-8. DOI: 10.1109/IEMBS.2010.5627126. View

12.

Chiang A, Huo X, Kavelaars A, Heijnen C . Chemotherapy accelerates age-related development of tauopathy and results in loss of synaptic integrity and cognitive impairment. Brain Behav Immun. 2019; 79:319-325. PMC: 6591052. DOI: 10.1016/j.bbi.2019.04.005. View

13.

Lomeli N, Di K, Czerniawski J, Guzowski J, Bota D . Cisplatin-induced mitochondrial dysfunction is associated with impaired cognitive function in rats. Free Radic Biol Med. 2016; 102:274-286. PMC: 5308450. DOI: 10.1016/j.freeradbiomed.2016.11.046. View

14.

Zeng Y, Cheng A, Song T, Sheng X, Wang S, Xie J . Effects of Acupuncture on Cancer-Related Cognitive Impairment in Chinese Gynecological Cancer Patients: A Pilot Cohort Study. Integr Cancer Ther. 2018; 17(3):737-746. PMC: 6142078. DOI: 10.1177/1534735418777109. View

15.

Lee B, Glass T, McAtee M, Wand G, Bandeen-Roche K, Bolla K . Associations of salivary cortisol with cognitive function in the Baltimore memory study. Arch Gen Psychiatry. 2007; 64(7):810-8. DOI: 10.1001/archpsyc.64.7.810. View

16.

Caron J, Krull K, Hockenberry M, Jain N, Kaemingk K, Moore I . Oxidative stress and executive function in children receiving chemotherapy for acute lymphoblastic leukemia. Pediatr Blood Cancer. 2009; 53(4):551-6. PMC: 3928629. DOI: 10.1002/pbc.22128. View

17.

Zhang Y, Chen Y, Hu L, You J, Gu W, Li Q . Chemotherapy-induced functional changes of the default mode network in patients with lung cancer. Brain Imaging Behav. 2019; 14(3):847-856. DOI: 10.1007/s11682-018-0030-y. View

18.

Koh Y, Tan C, Toh Y, Sze S, Ho H, Limoli C . Role of Exosomes in Cancer-Related Cognitive Impairment. Int J Mol Sci. 2020; 21(8). PMC: 7215650. DOI: 10.3390/ijms21082755. View

19.

Martin D, Liu R, Alonzo A, Green M, Loo C . Use of transcranial direct current stimulation (tDCS) to enhance cognitive training: effect of timing of stimulation. Exp Brain Res. 2014; 232(10):3345-51. DOI: 10.1007/s00221-014-4022-x. View

20.

Gietema J, Meinardi M, Messerschmidt J, Gelevert T, Alt F, Uges D . Circulating plasma platinum more than 10 years after cisplatin treatment for testicular cancer. Lancet. 2000; 355(9209):1075-6. DOI: 10.1016/s0140-6736(00)02044-4. View