» Articles » PMID: 32684760

Factors Associated with Early Complications in Inpatients Who Were Treated in Our Clinic Between 1992 and 2011 with a Diagnosis of Acute Bacterial Meningitis

Overview
Publisher Kare Publishing
Specialty Pediatrics
Date 2020 Jul 21
PMID 32684760
Citations 4
Authors
Affiliations
Soon will be listed here.
Abstract

Aim: To evaluate factors associated with the development of early complications in acute bacterial meningitis.

Material And Methods: In our study, 389 patients diagnosed with acute bacterial meningitis between January 1992 and January 2011 at Cerrahpaşa Medical Faculty were retrospectively analyzed to determine the risk factors for the development of early complications.

Results: The causative agent was in 17% of cases, S. pneumoniae in 13.6%, and in 6.4%. In 55.5% of cases, the causative agent could not be identified. The mortality rate was found as 1% and the early complication rate was 27.8%. The complications observed included septic shock and disseminated intravascular coagulation (33.3%), hydrocephalus (23.1%), subdural effusion (19.4%), and epilepsy (12%). Risk factors for early complications included being aged below two years (p<0.010), restlessness (p<0.010), rash (p<0.010), leukocytosis in complete blood count (p<0.010), and a cerebrospinal fluid glucose level of <45 mg/dL (p<0.010). Three of the four patients who died were male. The incidence of hydrocephalus was higher in patients who used ampicillin-cefotaxime and who did not receive steroid therapy before treatment (p<0.050).

Conclusion: When acute bacterial meningitis is treated properly and adequately, recovery without sequela is possible. Knowing the risk factors for early complications will guide in the monitoring of patients and decrease morbidity and mortality rates.

Citing Articles

Pneumococcal disease in children in the Middle East and Northern Africa: A systematic literature review of clinical burden, serotype distribution, and vaccination programs.

Ugrekhelidze D, Anis S, Sepek J, Grys M, Zalewska M, Pieniazek I Hum Vaccin Immunother. 2024; 20(1):2421630.

PMID: 39618022 PMC: 11622588. DOI: 10.1080/21645515.2024.2421630.


Post-Meningitic Syndrome: Pathophysiology and Consequences of Streptococcal Infections on the Central Nervous System.

Kaddoura R, Abdalbari K, Kadom M, Badla B, Abu Hijleh A, Hanifa M Int J Mol Sci. 2024; 25(20).

PMID: 39456835 PMC: 11507220. DOI: 10.3390/ijms252011053.


Global Burden and Its Association with Socioeconomic Development Status of Meningitis Caused by Specific Pathogens over the Past 30 years: A Population-Based Study.

Qu C, Wang Y, Wang X, He R, Cao H, Liu B Neuroepidemiology. 2023; 57(5):316-335.

PMID: 37399794 PMC: 10641806. DOI: 10.1159/000531508.


Systematic review of invasive meningococcal disease epidemiology in the Eastern Mediterranean and North Africa region.

Dogu A, Oordt-Speets A, van Kessel-de Bruijn F, Ceyhan M, Amiche A BMC Infect Dis. 2021; 21(1):1088.

PMID: 34686136 PMC: 8540099. DOI: 10.1186/s12879-021-06781-6.

References
1.
Chaudhuri A, Martinez-Martin P, Martin P, Kennedy P, Seaton R, Portegies P . EFNS guideline on the management of community-acquired bacterial meningitis: report of an EFNS Task Force on acute bacterial meningitis in older children and adults. Eur J Neurol. 2008; 15(7):649-59. DOI: 10.1111/j.1468-1331.2008.02193.x. View

2.
Dubos F, Korczowski B, Aygun D, Martinot A, Prat C, Galetto-Lacour A . Distinguishing between bacterial and aseptic meningitis in children: European comparison of two clinical decision rules. Arch Dis Child. 2010; 95(12):963-7. DOI: 10.1136/adc.2010.186056. View

3.
Ceyhan M, Yildirim I, Balmer P, Borrow R, Dikici B, Turgut M . A prospective study of etiology of childhood acute bacterial meningitis, Turkey. Emerg Infect Dis. 2008; 14(7):1089-96. PMC: 2600347. DOI: 10.3201/eid1407.070938. View

4.
Skarmeta M, Herrera P . [Prognostic factors in acute bacterial meningitis in children. A case control study]. Rev Med Chil. 1999; 126(11):1323-9. View

5.
Peng H, Hu Y, Chen H, Song P, Jiang L . Risk factors for poor prognosis in children with refractory purulent meningitis and the discharge criteria. J Infect Public Health. 2017; 11(2):238-242. DOI: 10.1016/j.jiph.2017.07.007. View