Spatial Distribution and Incidence Trend of Human Alveolar Echinococcosis in Southwest Germany: Increased Incidence and Urbanization of the Disease?

Overview

Journal Infection

Date 2020 Jul 18

PMID 32676946

Citations 2

Authors

Matthias C Mueller

Michael Marx

Gabriele Peyerl-Hoffmann

Winfried V Kern

Affiliations

Soon will be listed here.

Abstract

Ecology and epidemiology of Echinococcus multilocularis and human alveolar echinococcosis (AE) are changing in Central Europe. Our data from a regional referral center for AE in southwest Germany suggest rising regional incidence for AE (annual incidence per 100,000 population 2004-2011: 0.12; 2012-2019: 0.20) and emerging urban AE (of 7 cases of AE in Freiburg city dwellers none was diagnosed before 2012) calling for an intensification of E. multilocularis and AE surveillance and of AE prevention measures.

Citing Articles

Characteristics and Clinical Course of Alveolar Echinococcosis in Patients with Immunosuppression-Associated Conditions: A Retrospective Cohort Study.

Deibel A, Meyer Zu Schwabedissen C, Husmann L, Grimm F, Deplazes P, Reiner C Pathogens. 2022; 11(4).

PMID: 35456117 PMC: 9032794. DOI: 10.3390/pathogens11040441.

Integrative Analysis of RNA Expression and Regulatory Networks in Mice Liver Infected by .

Liu T, Li H, Li Y, Wang L, Chen G, Pu G Front Cell Dev Biol. 2022; 10:798551.

PMID: 35399512 PMC: 8989267. DOI: 10.3389/fcell.2022.798551.

References

Schneider R, Aspock H, Auer H . Unexpected increase of alveolar echincoccosis, Austria, 2011. Emerg Infect Dis. 2013; 19(3):475-7. PMC: 3647648. DOI: 10.3201/eid1903.120595. View

Stieger C, Hegglin D, SCHWARZENBACH G, Mathis A, Deplazes P . Spatial and temporal aspects of urban transmission of Echinococcus multilocularis. Parasitology. 2002; 124(Pt 6):631-40. DOI: 10.1017/s0031182002001749. View

Hofer S, Gloor S, Muller U, Mathis A, Hegglin D, Deplazes P . High prevalence of Echinococcus multilocularis in urban red foxes (Vulpes vulpes) and voles (Arvicola terrestris) in the city of Zürich, Switzerland. Parasitology. 2000; 120 ( Pt 2):135-42. DOI: 10.1017/s0031182099005351. View

Vuitton D, Demonmerot F, Knapp J, Richou C, Grenouillet F, Chauchet A . Clinical epidemiology of human AE in Europe. Vet Parasitol. 2015; 213(3-4):110-20. DOI: 10.1016/j.vetpar.2015.07.036. View

Schweiger A, Ammann R, Candinas D, Clavien P, Eckert J, Gottstein B . Human alveolar echinococcosis after fox population increase, Switzerland. Emerg Infect Dis. 2007; 13(6):878-82. PMC: 2792858. DOI: 10.3201/eid1306.061074. View

Hegglin D, Deplazes P . Control of Echinococcus multilocularis: strategies, feasibility and cost-benefit analyses. Int J Parasitol. 2013; 43(5):327-37. DOI: 10.1016/j.ijpara.2012.11.013. View

Romig T, Kratzer W, Kimmig P, Frosch M, Gaus W, Flegel W . An epidemiologic survey of human alveolar echinococcosis in southwestern Germany. Römerstein Study Group. Am J Trop Med Hyg. 1999; 61(4):566-73. DOI: 10.4269/ajtmh.1999.61.566. View

Nothdurft H, Jelinek T, Mai A, Sigl B, von Sonnenburg F, Loscher T . Epidemiology of alveolar echinococcosis in southern Germany (Bavaria). Infection. 1995; 23(2):85-8. DOI: 10.1007/BF01833871. View

Gottstein B, Saucy F, Deplazes P, Reichen J, Demierre G, Busato A . Is high prevalence of Echinococcus multilocularis in wild and domestic animals associated with disease incidence in humans?. Emerg Infect Dis. 2001; 7(3):408-12. PMC: 2631798. DOI: 10.3201/eid0703.010307. View

10.

Jorgensen P, An der Heiden M, Kern P, Schoneberg I, Krause G, Alpers K . Underreporting of human alveolar echinococcosis, Germany. Emerg Infect Dis. 2008; 14(6):935-7. PMC: 2600310. DOI: 10.3201/eid1406.071173. View

11.

Brunetti E, Kern P, Vuitton D . Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans. Acta Trop. 2009; 114(1):1-16. DOI: 10.1016/j.actatropica.2009.11.001. View

12.

Deplazes P, Hegglin D, Gloor S, Romig T . Wilderness in the city: the urbanization of Echinococcus multilocularis. Trends Parasitol. 2004; 20(2):77-84. DOI: 10.1016/j.pt.2003.11.011. View

13.

Gottstein B, Stojkovic M, Vuitton D, Millon L, Marcinkute A, Deplazes P . Threat of alveolar echinococcosis to public health--a challenge for Europe. Trends Parasitol. 2015; 31(9):407-12. DOI: 10.1016/j.pt.2015.06.001. View

14.

Jenkins D, Romig T, Thompson R . Emergence/re-emergence of Echinococcus spp.--a global update. Int J Parasitol. 2005; 35(11-12):1205-19. DOI: 10.1016/j.ijpara.2005.07.014. View

15.

Schmidberger J, Kratzer W, Stark K, Gruner B . Alveolar echinococcosis in Germany, 1992-2016. An update based on the newly established national AE database. Infection. 2017; 46(2):197-206. DOI: 10.1007/s15010-017-1094-0. View