Fgf10/Fgfr2b Signaling in Mammary Gland Development, Homeostasis, and Cancer

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2020 Jul 18

PMID 32676501

Citations 10

Authors

Stefano Rivetti

Chaolei Chen

Chengshui Chen

Saverio Bellusci

Affiliations

Soon will be listed here.

Abstract

Fibroblast growth factor 10 (Fgf10) is a secreted ligand acting via the Fibroblast growth factor receptor 2b (Fgfr2b). Fgf10/Fgfr2b signaling plays important roles both in the epithelium and in the mesenchyme during mammary gland development. Evidence in mice show that Fgf10 is critical for the induction of four out of five of the mammary placodes and for the formation of the white adipose tissue. Fgfr2b ligands also play important function in the maintenance of the terminal end buds, specialized structures at the tip of the ramified ducts during the postnatal phase of mammary gland development. Finally, in humans, FGF10 has been described to be expressed in 10% of the breast adenocarcinoma and activation of FGFR2b signaling correlates with a worse prognostic. Therefore, Fgf10 plays pleiotropic roles in both mammary gland development, homeostasis and cancer and elucidating its mechanism of action and cellular targets will be crucial to either enhance mammary gland development or to find innovative targets to treat aggressive breast cancer.

Citing Articles

Embryonic Mammary Gland Morphogenesis.

Myllymaki S, Lan Q, Mikkola M Adv Exp Med Biol. 2025; 1464():9-27.

PMID: 39821018 DOI: 10.1007/978-3-031-70875-6_2.

Mesenchyme instructs growth while epithelium directs branching in the mouse mammary gland.

Lan Q, Trela E, Lindstrom R, Satta J, Kaczynska B, Christensen M Elife. 2024; 13.

PMID: 38441552 PMC: 10959526. DOI: 10.7554/eLife.93326.

FGFR2 Controls Growth, Adhesion and Migration of Nontumorigenic Human Mammary Epithelial Cells by Regulation of Integrin β1 Degradation.

Mieczkowski K, Popeda M, Lesniak D, Sadej R, Kitowska K J Mammary Gland Biol Neoplasia. 2023; 28(1):9.

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Natural Killer Cell Derived Microvesicles Affect the Function of Trophoblast Cells.

Sokolov D, Gorshkova A, Markova K, Milyutina Y, Pyatygina K, Zementova M Membranes (Basel). 2023; 13(2).

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Sci-Seq of Human Fetal Salivary Tissue Introduces Human Transcriptional Paradigms and a Novel Cell Population.

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