Diet Composition Affects Liver and Mammary Tissue Transcriptome in Primiparous Holstein Dairy Cows

Overview

Journal Animals (Basel)

Date 2020 Jul 18

PMID 32674414

Authors

Shengtao Gao

Zheng Zhou

Jiaqi Wang

Juan Loor

Massimo Bionaz

Lu Ma

Dengpan Bu

Affiliations

Soon will be listed here.

Abstract

The objective of the present study was to evaluate the overall adaptations of liver and mammary tissue to a corn stover (CS) compared to a mixed forage (MF) diet in mid-lactation primiparous dairy cows. Twenty-four primiparous lactating Holstein cows were randomly allocated to 2 groups receiving either an alfalfa forage diet (MF, F:C = 60:40) with Chinese wildrye, alfalfa hay and corn silage as forage source or a corn stover forage diet (CS, F:C = 40:60). A subgroup of cows (n = 5/diet) was used for analysis of liver and mammary transcriptome using a 4 × 44K Bovine Agilent microarray chip. The results of functional annotation analysis showed that in liver CS vs. MF inhibited pathways related to lipid metabolism while induced the activity of the potassium channel. In mammary tissue, fatty acid metabolism was activated in CS vs. MF. In conclusion, the analysis of genes affected by CS vs. MF indicated mammary gland responding to lower level of linoleate from the diet (lower in CS vs. MF) by activating the associated biosynthesis metabolic pathway while the liver adaptively activated potassium transport to compensate for a lower K ingestion.

References

Bindea G, Mlecnik B, Hackl H, Charoentong P, Tosolini M, Kirilovsky A . ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks. Bioinformatics. 2009; 25(8):1091-3. PMC: 2666812. DOI: 10.1093/bioinformatics/btp101. View

Sid V, Siow Y, O K . Role of folate in nonalcoholic fatty liver disease. Can J Physiol Pharmacol. 2017; 95(10):1141-1148. DOI: 10.1139/cjpp-2016-0681. View

Huang D, Sherman B, Lempicki R . Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 2009; 4(1):44-57. DOI: 10.1038/nprot.2008.211. View

Fimia G, Sassone-Corsi P . Cyclic AMP signalling. J Cell Sci. 2001; 114(Pt 11):1971-2. DOI: 10.1242/jcs.114.11.1971. View

Loor J, Everts R, Bionaz M, Dann H, Morin D, Oliveira R . Nutrition-induced ketosis alters metabolic and signaling gene networks in liver of periparturient dairy cows. Physiol Genomics. 2007; 32(1):105-16. DOI: 10.1152/physiolgenomics.00188.2007. View

Bionaz M, Loor J . Ruminant metabolic systems biology: reconstruction and integration of transcriptome dynamics underlying functional responses of tissues to nutrition and physiological state. Gene Regul Syst Bio. 2012; 6:109-25. PMC: 3394460. DOI: 10.4137/GRSB.S9852. View

Boczek T, Cameron E, Yu W, Xia X, Shah S, Castillo Chabeco B . Regulation of Neuronal Survival and Axon Growth by a Perinuclear cAMP Compartment. J Neurosci. 2019; 39(28):5466-5480. PMC: 6616289. DOI: 10.1523/JNEUROSCI.2752-18.2019. View

Zhou X, Zhang Y, Zhao M, Zhang T, Zhu D, Bu D . Effect of dietary energy source and level on nutrient digestibility, rumen microbial protein synthesis, and milk performance in lactating dairy cows. J Dairy Sci. 2015; 98(10):7209-17. DOI: 10.3168/jds.2015-9312. View

Bauman D, Mather I, Wall R, Lock A . Major advances associated with the biosynthesis of milk. J Dairy Sci. 2006; 89(4):1235-43. DOI: 10.3168/jds.S0022-0302(06)72192-0. View

10.

Brasier A . The NF-kappaB regulatory network. Cardiovasc Toxicol. 2007; 6(2):111-30. DOI: 10.1385/ct:6:2:111. View

11.

Busato S, Bionaz M . The interplay between non-esterified fatty acids and bovine peroxisome proliferator-activated receptors: results of an hybrid approach. J Anim Sci Biotechnol. 2020; 11:91. PMC: 7419192. DOI: 10.1186/s40104-020-00481-y. View

12.

Bergman E, Brockman R, Kaufman C . Glucose metabolism in ruminants: comparison of whole-body turnover with production by gut, liver, and kidneys. Fed Proc. 1974; 33(7):1849-54. View

13.

Mandard S, Muller M, Kersten S . Peroxisome proliferator-activated receptor alpha target genes. Cell Mol Life Sci. 2004; 61(4):393-416. PMC: 11138883. DOI: 10.1007/s00018-003-3216-3. View

14.

Bu D, Bionaz M, Wang M, Nan X, Ma L, Wang J . Transcriptome difference and potential crosstalk between liver and mammary tissue in mid-lactation primiparous dairy cows. PLoS One. 2017; 12(3):e0173082. PMC: 5349457. DOI: 10.1371/journal.pone.0173082. View

15.

You L . Steroid hormone biotransformation and xenobiotic induction of hepatic steroid metabolizing enzymes. Chem Biol Interact. 2004; 147(3):233-46. DOI: 10.1016/j.cbi.2004.01.006. View

16.

Falkenstein E, Tillmann H, Christ M, Feuring M, Wehling M . Multiple actions of steroid hormones--a focus on rapid, nongenomic effects. Pharmacol Rev. 2000; 52(4):513-56. View

17.

Steinberg S, Campbell C, HILLMAN R . Kinetics of the normal folate enterohepatic cycle. J Clin Invest. 1979; 64(1):83-8. PMC: 372093. DOI: 10.1172/JCI109467. View

18.

Loor J, Bionaz M, Drackley J . Systems physiology in dairy cattle: nutritional genomics and beyond. Annu Rev Anim Biosci. 2014; 1:365-92. DOI: 10.1146/annurev-animal-031412-103728. View

19.

Aschenbach J, Kristensen N, Donkin S, Hammon H, Penner G . Gluconeogenesis in dairy cows: the secret of making sweet milk from sour dough. IUBMB Life. 2010; 62(12):869-77. DOI: 10.1002/iub.400. View

20.

Shahzad K, Bionaz M, Trevisi E, Bertoni G, Rodriguez-Zas S, Loor J . Integrative analyses of hepatic differentially expressed genes and blood biomarkers during the peripartal period between dairy cows overfed or restricted-fed energy prepartum. PLoS One. 2014; 9(6):e99757. PMC: 4051754. DOI: 10.1371/journal.pone.0099757. View