Oxidative Stress Response Associates with the Teratogenic Effects of Benzyl Butyl Phthalate (BBP)

Overview

Journal Toxicol Res (Camb)

Publisher Oxford University Press

Date 2020 Jul 17

PMID 32670553

Citations 4

Authors

Ge Song

Rui Wang

Yi Cui

Chan Juan Hao

Hong-Fei Xia

Xu Ma

Affiliations

Soon will be listed here.

Abstract

Benzyl butyl phthalate (BBP) is a persistent environmental pollutant. BBP exposure and the possible effects on human neural tube defects (NTDs) remain elusive. In this study, we found that the detection ratio of positive BBP and its metabolites in maternal urine was obviously higher in NTDs' population than that in normal controls by GC-MS ( 0.01, 0.05, respectively). Animal experiments showed that BBP treatment induced developmental toxicity in chick embryo by enhancing the levels of oxidative stress and cell apoptosis ( 0.01). More interestingly, the supplement of high-dose choline (CHO, 10 μg/mL) could partially restore the teratogenic effects of BBP by inhibiting the occurrence of oxidative stress. Our data collectively suggest that BBP exposure may disturb neural tube development by strengthening oxidative stress. CHO can partially restore the toxicity effects of BBP. This study may provide new insight for NTD prevention.

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