Insight into Atrial Fibrillation Through Analysis of the Coding Transcriptome in Humans

Overview

Journal Biophys Rev

Publisher Springer

Specialty Biophysics

Date 2020 Jul 16

PMID 32666467

Citations 11

Authors

Marja Steenman

Affiliations

Soon will be listed here.

Abstract

Atrial fibrillation is the most common sustained cardiac arrhythmia in humans, and its prevalence continues to increase because of the aging of the world population. Much still needs to be learned about the molecular pathways involved in the development and the persistence of the disease. Analysis of the transcriptome of cardiac tissue has provided valuable insight into diverse aspects of atrial remodeling, in particular concerning electrical remodeling-related to ion channels-and structural remodeling identified by dysregulation of processes linked to inflammation, fibrosis, oxidative stress, and thrombogenesis. The huge amount of data produced by these studies now represents a valuable source for the identification of novel potential therapeutic targets. In addition, the shift from cardiac tissue to peripheral blood as a substrate for transcriptome analysis revealed this strategy as a promising tool for improved diagnosis and therefore better patient care.

Citing Articles

The cardiac blood transcriptome predicts de novo onset of atrial fibrillation in heart failure.

Lamirault G, Fellah-Hebia I, Chevalier C, Guisle I, Guyomarch B, Solnon A J Mol Cell Cardiol Plus. 2025; 8():100077.

PMID: 39802916 PMC: 11708251. DOI: 10.1016/j.jmccpl.2024.100077.

Genetics, transcriptomics, metagenomics, and metabolomics in the pathogenesis and prediction of atrial fibrillation.

Linna-Kuosmanen S, Vuori M, Kiviniemi T, Palmu J, Niiranen T Eur Heart J Suppl. 2024; 26(Suppl 4):iv33-iv40.

PMID: 39099578 PMC: 11292413. DOI: 10.1093/eurheartjsupp/suae072.

Atrial cardiomyopathy revisited-evolution of a concept: a clinical consensus statement of the European Heart Rhythm Association (EHRA) of the ESC, the Heart Rhythm Society (HRS), the Asian Pacific Heart Rhythm Society (APHRS), and the Latin American....

Goette A, Corradi D, Dobrev D, Aguinaga L, Cabrera J, Chugh S Europace. 2024; 26(9).

PMID: 39077825 PMC: 11431804. DOI: 10.1093/europace/euae204.

Compartmentalization proteomics revealed endolysosomal protein network changes in a goat model of atrial fibrillation.

Ayagama T, Charles P, Bose S, Boland B, Priestman D, Aston D iScience. 2024; 27(6):109609.

PMID: 38827406 PMC: 11141153. DOI: 10.1016/j.isci.2024.109609.

Atrial fibrillation: mechanism and clinical management.

Hu Z, Ding L, Yao Y Chin Med J (Engl). 2023; 136(22):2668-2676.

PMID: 37914663 PMC: 10684204. DOI: 10.1097/CM9.0000000000002906.

References

Andrews T, Reimold S, Berlin J, Antman E . Prevention of supraventricular arrhythmias after coronary artery bypass surgery. A meta-analysis of randomized control trials. Circulation. 1991; 84(5 Suppl):III236-44. View

Ko D, Benson M, Ngo D, Yang Q, Larson M, Wang T . Proteomics Profiling and Risk of New-Onset Atrial Fibrillation: Framingham Heart Study. J Am Heart Assoc. 2019; 8(6):e010976. PMC: 6475036. DOI: 10.1161/JAHA.118.010976. View

Nao T, Ohkusa T, Hisamatsu Y, Inoue N, Matsumoto T, Yamada J . Comparison of expression of connexin in right atrial myocardium in patients with chronic atrial fibrillation versus those in sinus rhythm. Am J Cardiol. 2003; 91(6):678-83. DOI: 10.1016/s0002-9149(02)03403-3. View

Haegeli L, Calkins H . Catheter ablation of atrial fibrillation: an update. Eur Heart J. 2014; 35(36):2454-9. DOI: 10.1093/eurheartj/ehu291. View

Yeh Y, Kuo C, Lee Y, Lin Y, Nattel S, Tsai F . Region-specific gene expression profiles in the left atria of patients with valvular atrial fibrillation. Heart Rhythm. 2012; 10(3):383-91. DOI: 10.1016/j.hrthm.2012.11.013. View

Brundel B, van Gelder I, Henning R, Tieleman R, Tuinenburg A, Wietses M . Ion channel remodeling is related to intraoperative atrial effective refractory periods in patients with paroxysmal and persistent atrial fibrillation. Circulation. 2001; 103(5):684-90. DOI: 10.1161/01.cir.103.5.684. View

Suhling M, Wolke C, Scharf C, Lendeckel U . Proteomics and transcriptomics in atrial fibrillation. Herzschrittmacherther Elektrophysiol. 2018; 29(1):70-75. DOI: 10.1007/s00399-017-0551-x. View

Kannel W, Feinleib M, MCNAMARA P, Garrison R, CASTELLI W . An investigation of coronary heart disease in families. The Framingham offspring study. Am J Epidemiol. 1979; 110(3):281-90. DOI: 10.1093/oxfordjournals.aje.a112813. View

Iwasaki Y, Nishida K, Kato T, Nattel S . Atrial fibrillation pathophysiology: implications for management. Circulation. 2011; 124(20):2264-74. DOI: 10.1161/CIRCULATIONAHA.111.019893. View

10.

Rahman F, Kwan G, Benjamin E . Global epidemiology of atrial fibrillation. Nat Rev Cardiol. 2014; 11(11):639-54. DOI: 10.1038/nrcardio.2014.118. View

11.

Jickling G, Xu H, Stamova B, Ander B, Zhan X, Tian Y . Signatures of cardioembolic and large-vessel ischemic stroke. Ann Neurol. 2010; 68(5):681-92. PMC: 2967466. DOI: 10.1002/ana.22187. View

12.

Kawashima Y, Nagasawa T, Ninomiya H . Contribution of ecto-5'-nucleotidase to the inhibition of platelet aggregation by human endothelial cells. Blood. 2000; 96(6):2157-62. View

13.

Zoni-Berisso M, Lercari F, Carazza T, Domenicucci S . Epidemiology of atrial fibrillation: European perspective. Clin Epidemiol. 2014; 6:213-20. PMC: 4064952. DOI: 10.2147/CLEP.S47385. View

14.

Lamirault G, Gaborit N, le Meur N, Chevalier C, Lande G, Demolombe S . Gene expression profile associated with chronic atrial fibrillation and underlying valvular heart disease in man. J Mol Cell Cardiol. 2005; 40(1):173-84. DOI: 10.1016/j.yjmcc.2005.09.004. View

15.

Kirchhof P, Benussi S, Kotecha D, Ahlsson A, Atar D, Casadei B . 2016 ESC Guidelines for the Management of Atrial Fibrillation Developed in Collaboration With EACTS. Rev Esp Cardiol (Engl Ed). 2017; 70(1):50. DOI: 10.1016/j.rec.2016.11.033. View

16.

Gaborit N, Steenman M, Lamirault G, le Meur N, Le Bouter S, Lande G . Human atrial ion channel and transporter subunit gene-expression remodeling associated with valvular heart disease and atrial fibrillation. Circulation. 2005; 112(4):471-81. DOI: 10.1161/CIRCULATIONAHA.104.506857. View

17.

Kim Y, Lim D, Lee J, Lim D, Shim W, Ro Y . Gene expression profiling of oxidative stress on atrial fibrillation in humans. Exp Mol Med. 2003; 35(5):336-49. DOI: 10.1038/emm.2003.45. View

18.

Andrade J, Khairy P, Dobrev D, Nattel S . The clinical profile and pathophysiology of atrial fibrillation: relationships among clinical features, epidemiology, and mechanisms. Circ Res. 2014; 114(9):1453-68. DOI: 10.1161/CIRCRESAHA.114.303211. View

19.

Whitlock R, Teoh K, Vincent J, Devereaux P, Lamy A, Paparella D . Rationale and design of the steroids in cardiac surgery trial. Am Heart J. 2014; 167(5):660-5. DOI: 10.1016/j.ahj.2014.01.018. View

20.

Chen Y, Xu S, Bendahhou S, Wang X, Wang Y, Xu W . KCNQ1 gain-of-function mutation in familial atrial fibrillation. Science. 2003; 299(5604):251-4. DOI: 10.1126/science.1077771. View