Insight into Atrial Fibrillation Through Analysis of the Coding Transcriptome in Humans
Overview
Authors
Affiliations
Atrial fibrillation is the most common sustained cardiac arrhythmia in humans, and its prevalence continues to increase because of the aging of the world population. Much still needs to be learned about the molecular pathways involved in the development and the persistence of the disease. Analysis of the transcriptome of cardiac tissue has provided valuable insight into diverse aspects of atrial remodeling, in particular concerning electrical remodeling-related to ion channels-and structural remodeling identified by dysregulation of processes linked to inflammation, fibrosis, oxidative stress, and thrombogenesis. The huge amount of data produced by these studies now represents a valuable source for the identification of novel potential therapeutic targets. In addition, the shift from cardiac tissue to peripheral blood as a substrate for transcriptome analysis revealed this strategy as a promising tool for improved diagnosis and therefore better patient care.
The cardiac blood transcriptome predicts de novo onset of atrial fibrillation in heart failure.
Lamirault G, Fellah-Hebia I, Chevalier C, Guisle I, Guyomarch B, Solnon A J Mol Cell Cardiol Plus. 2025; 8():100077.
PMID: 39802916 PMC: 11708251. DOI: 10.1016/j.jmccpl.2024.100077.
Linna-Kuosmanen S, Vuori M, Kiviniemi T, Palmu J, Niiranen T Eur Heart J Suppl. 2024; 26(Suppl 4):iv33-iv40.
PMID: 39099578 PMC: 11292413. DOI: 10.1093/eurheartjsupp/suae072.
Goette A, Corradi D, Dobrev D, Aguinaga L, Cabrera J, Chugh S Europace. 2024; 26(9).
PMID: 39077825 PMC: 11431804. DOI: 10.1093/europace/euae204.
Ayagama T, Charles P, Bose S, Boland B, Priestman D, Aston D iScience. 2024; 27(6):109609.
PMID: 38827406 PMC: 11141153. DOI: 10.1016/j.isci.2024.109609.
Atrial fibrillation: mechanism and clinical management.
Hu Z, Ding L, Yao Y Chin Med J (Engl). 2023; 136(22):2668-2676.
PMID: 37914663 PMC: 10684204. DOI: 10.1097/CM9.0000000000002906.