Autogenous Dentin Graft in Bone Defects After Lower Third Molar Extraction: A Split-Mouth Clinical Trial

Overview

Journal Materials (Basel)

Publisher MDPI

Date 2020 Jul 16

PMID 32664303

Citations 14

Authors

Luis Sanchez-Labrador

Maria Martin-Ares

Ricardo Ortega-Aranegui

Juan Lopez-Quiles

Jose Maria Martinez-Gonzalez

Affiliations

Soon will be listed here.

Abstract

Various biomaterials are currently used for bone regeneration, with autogenous bone being considered the gold standard material because of its osteogenic, osteoconductive, and osteoinductive properties. In recent years, the use of autogenous dentin as a graft material has been described. This split-mouth clinical trial assesses the efficacy of autogenous dentin for the regeneration of periodontal defects caused by bone loss associated with impacted lower third molar extraction. Fifteen patients underwent bilateral extraction surgery (30 third molars) using dentin as a graft material on the test side, and leaving the control side to heal spontaneously, comparing the evolution of the defects by evaluating probing depth at three and six months post-operatively. Bone density and alveolar bone crest maintenance were also evaluated six months after surgery, and pain, inflammation, mouth opening capacity on the second and seventh days after surgery. Probing depth, radiographic bone density, and alveolar bone crest maintenance showed significant differences between the test and control sides. Autogenous dentin was found to be an effective biomaterial for bone regeneration after impacted lower third molar extraction.

Citing Articles

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References

Amin M, Laskin D . Prophylactic use of indomethacin for prevention of postsurgical complications after removal of impacted third molars. Oral Surg Oral Med Oral Pathol. 1983; 55(5):448-51. DOI: 10.1016/0030-4220(83)90227-x. View

Ge J, Yang C, Zheng J, Hu Y . Autogenous bone grafting for treatment of osseous defect after impacted mandibular third molar extraction: A randomized controlled trial. Clin Implant Dent Relat Res. 2016; 19(3):572-580. DOI: 10.1111/cid.12466. View

Pang K, Um I, Kim Y, Woo J, Kim S, Lee J . Autogenous demineralized dentin matrix from extracted tooth for the augmentation of alveolar bone defect: a prospective randomized clinical trial in comparison with anorganic bovine bone. Clin Oral Implants Res. 2016; 28(7):809-815. DOI: 10.1111/clr.12885. View

Dodson T . Is there a role for reconstructive techniques to prevent periodontal defects after third molar surgery?. J Oral Maxillofac Surg. 2005; 63(7):891-6. DOI: 10.1016/j.joms.2005.03.003. View

Pons-Vicente O, Valmaseda-Castellon E, Berini-Aytes L, Gay-Escoda C . Effect on pocket depth and attachment level of manual versus ultrasonic scaling of lower second molars following lower third molar extraction: a randomized controlled trial. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009; 107(3):e11-9. DOI: 10.1016/j.tripleo.2008.12.001. View

Pohl S, Binderman I, Tomac J . Maintenance of Alveolar Ridge Dimensions Utilizing an Extracted Tooth Dentin Particulate Autograft and PlateletRich Fibrin: A Retrospective Radiographic ConeBeam Computed Tomography Study. Materials (Basel). 2020; 13(5). PMC: 7084901. DOI: 10.3390/ma13051083. View

Haugen H, Lyngstadaas S, Rossi F, Perale G . Bone grafts: which is the ideal biomaterial?. J Clin Periodontol. 2019; 46 Suppl 21:92-102. DOI: 10.1111/jcpe.13058. View

Leung W, THEILADE E, Comfort M, Lim P . Microbiology of the pericoronal pouch in mandibular third molar pericoronitis. Oral Microbiol Immunol. 1993; 8(5):306-12. DOI: 10.1111/j.1399-302x.1993.tb00579.x. View

Kabir M, Murata M, Akazawa T, Kusano K, Yamada K, Ito M . Evaluation of perforated demineralized dentin scaffold on bone regeneration in critical-size sheep iliac defects. Clin Oral Implants Res. 2017; 28(11):e227-e235. DOI: 10.1111/clr.13000. View

10.

Camps-Font O, Caro-Bonfill C, Sanchez-Garces M, Gay-Escoda C . Periodontal Regenerative Therapy for Preventing Bone Defects Distal to Mandibular Second Molars After Surgical Removal of Impacted Third Molars: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. J Oral Maxillofac Surg. 2018; 76(12):2482-2514. DOI: 10.1016/j.joms.2018.07.025. View

11.

Cobo-Vazquez C, Fernandez-Tresguerres I, Ortega-Aranegui R, Lopez-Quiles J . Effects of local melatonin application on post-extraction sockets after third molar surgery. A pilot study. Med Oral Patol Oral Cir Bucal. 2014; 19(6):e628-33. PMC: 4259382. DOI: 10.4317/medoral.19851. View

12.

Kugelberg C, Ahlstrom U, Ericson S, Hugoson A . Periodontal healing after impacted lower third molar surgery. A retrospective study. Int J Oral Surg. 1985; 14(1):29-40. DOI: 10.1016/s0300-9785(85)80007-7. View

13.

Richardson D, Dodson T . Risk of periodontal defects after third molar surgery: An exercise in evidence-based clinical decision-making. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005; 100(2):133-7. DOI: 10.1016/j.tripleo.2005.02.063. View

14.

Hassan K, Marei H, Alagl A . Does grafting of third molar extraction sockets enhance periodontal measures in 30- to 35-year-old patients?. J Oral Maxillofac Surg. 2011; 70(4):757-64. DOI: 10.1016/j.joms.2011.09.010. View

15.

Del Canto-Diaz A, de Elio-Oliveros J, Del Canto-Diaz M, Alobera-Gracia M, Del Canto-Pingarron M, Martinez-Gonzalez J . Use of autologous tooth-derived graft material in the post-extraction dental socket. Pilot study. Med Oral Patol Oral Cir Bucal. 2018; 24(1):e53-e60. PMC: 6344012. DOI: 10.4317/medoral.22536. View

16.

de Oliveira G, Miziara M, da Silva E, Ferreira E, Biulchi A, Alves J . Enhanced bone formation during healing process of tooth sockets filled with demineralized human dentine matrix. Aust Dent J. 2013; 58(3):326-32. DOI: 10.1111/adj.12088. View

17.

Petsos H, Korte J, Eickholz P, Hoffmann T, Borchard R . Surgical removal of third molars and periodontal tissues of adjacent second molars. J Clin Periodontol. 2016; 43(5):453-60. DOI: 10.1111/jcpe.12527. View

18.

Coleman M, McCormick A, Laskin D . The incidence of periodontal defects distal to the maxillary second molar after impacted third molar extraction. J Oral Maxillofac Surg. 2010; 69(2):319-21. DOI: 10.1016/j.joms.2010.10.011. View

19.

Inocencio Faria A, Gallas-Torreira M, Lopez-Raton M . Mandibular second molar periodontal healing after impacted third molar extraction in young adults. J Oral Maxillofac Surg. 2012; 70(12):2732-41. DOI: 10.1016/j.joms.2012.07.044. View

20.

Lee C, Hum L, Chen Y . The effect of regenerative periodontal therapy in preventing periodontal defects after the extraction of third molars: A systematic review and meta-analysis. J Am Dent Assoc. 2016; 147(9):709-719.e4. DOI: 10.1016/j.adaj.2016.03.005. View