Sorbicillinoid Derivatives From Sponge-Derived Fungus (HN-2016-018)

Overview

Journal Front Microbiol

Specialty Microbiology

Date 2020 Jul 14

PMID 32655528

Citations 11

Authors

Saif Ur Rehman

Lu-Jia Yang

Ya-Hui Zhang

Jing-Shuai Wu

Ting Shi

Waqas Haider

Chang-Lun Shao

Chang-Yun Wang

Affiliations

Soon will be listed here.

Abstract

Six new sorbicillinoids, trichoreeseione A () and B (), trichodermolide B (), 13-hydroxytrichodermolide (), 24-hydroxy-trichodimerol (), 15-hydroxybisvertinol (), together with three known analogs, trichodimerol (), 24-hydroxybisvertinol (), and bisvertinol (), were isolated from the sponge-derived fungus (HN-2016-018). Their structures including absolute configurations were elucidated by analysis of NMR, MS data, and calculated ECD spectra. Compounds and with a characteristic naphthalene-trione ring were firstly reported in sorbicillinoid family. Compounds and were two rare sorbicillinoids containing a unique bicycle [3.2.1] lactone skeleton, while with a propan-2-one moiety was also recorded first time in this family. Compound displayed cytotoxic activity against A549, MCF-7, and HCT116 cell lines with the IC values of 5.1, 9.5, and 13.7 μM, respectively.

Citing Articles

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