Transcriptional and Posttranscriptional Regulation of CSF-1 Gene Expression in Human Monocytes

Overview

Journal Mol Cell Biol

Specialty Cell Biology

Date 1988 Sep 1

PMID 3265472

Citations 12

Authors

J Horiguchi

E Sariban

D Kufe

Affiliations

Soon will be listed here.

Abstract

Regulation of CSF-1 gene expression was investigated in human monocytes. CSF-1 transcripts were at low or undetectable levels in resting monocytes. However, in monocytes treated with 12-O-tetradecanoylphorbol-13-acetate (TPA), CSF-1 mRNA was increased by 3 h and reached maximal levels by 12 h of drug exposure. When nuclear run-on assays were used, CSF-1 gene transcription was also at low or undetectable levels in resting monocytes but was activated after TPA exposure. TPA-treated monocytes exposed to actinomycin D further demonstrated that the half-life of the CSF-1 mRNA is 0.9 h. The results also demonstrated that the protein synthesis inhibitor, cycloheximide (CHX), increases CSF-1 mRNA levels in both resting and TPA-treated monocytes. These effects of CHX occurred in the absence of detectable increases in CSF-1 gene transcription. Moreover, treatment of monocytes with CHX and actinomycin D demonstrated that inhibition of protein synthesis is associated with stabilization of the CSF-1 transcript. Taken together, these findings indicated that CSF-1 gene expression is controlled at both transcriptional and posttranscriptional levels in human monocytes.

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References

Stanley E, Heard P . Factors regulating macrophage production and growth. Purification and some properties of the colony stimulating factor from medium conditioned by mouse L cells. J Biol Chem. 1977; 252(12):4305-12. View

Sariban E, Imamura K, Luebbers R, Kufe D . Transcriptional and posttranscriptional regulation of tumor necrosis factor gene expression in human monocytes. J Clin Invest. 1988; 81(5):1506-10. PMC: 442583. DOI: 10.1172/JCI113482. View

Cleveland D, Lopata M, MacDonald R, Cowan N, Rutter W, Kirschner M . Number and evolutionary conservation of alpha- and beta-tubulin and cytoplasmic beta- and gamma-actin genes using specific cloned cDNA probes. Cell. 1980; 20(1):95-105. DOI: 10.1016/0092-8674(80)90238-x. View

Lanotte M, Metcalf D, Dexter T . Production of monocyte/macrophage colony-stimulating factor by preadipocyte cell lines derived from murine marrow stroma. J Cell Physiol. 1982; 112(1):123-7. DOI: 10.1002/jcp.1041120118. View

Muller R, TREMBLAY J, Adamson E, Verma I . Tissue and cell type-specific expression of two human c-onc genes. Nature. 1983; 304(5925):454-6. DOI: 10.1038/304454a0. View

Stanley E, Guilbert L, Tushinski R, Bartelmez S . CSF-1--a mononuclear phagocyte lineage-specific hemopoietic growth factor. J Cell Biochem. 1983; 21(2):151-9. DOI: 10.1002/jcb.240210206. View

Sherr C, Rettenmier C, Sacca R, Roussel M, Look A, Stanley E . The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF-1. Cell. 1985; 41(3):665-76. DOI: 10.1016/s0092-8674(85)80047-7. View

Sariban E, Mitchell T, Kufe D . Expression of the c-fms proto-oncogene during human monocytic differentiation. Nature. 1985; 316(6023):64-6. DOI: 10.1038/316064a0. View

Nienhuis A, BUNN H, Turner P, Gopal T, Nash W, OBrien S . Expression of the human c-fms proto-oncogene in hematopoietic cells and its deletion in the 5q- syndrome. Cell. 1985; 42(2):421-8. DOI: 10.1016/0092-8674(85)90099-6. View

10.

Kawasaki E, Ladner M, Wang A, Van Arsdell J, Warren M, Coyne M . Molecular cloning of a complementary DNA encoding human macrophage-specific colony-stimulating factor (CSF-1). Science. 1985; 230(4723):291-6. DOI: 10.1126/science.2996129. View

11.

Caput D, Beutler B, Hartog K, Thayer R, Cerami A . Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators. Proc Natl Acad Sci U S A. 1986; 83(6):1670-4. PMC: 323145. DOI: 10.1073/pnas.83.6.1670. View

12.

Ralph P, Warren M, Lee M, Csejtey J, Weaver J, Broxmeyer H . Inducible production of human macrophage growth factor, CSF-1. Blood. 1986; 68(3):633-9. View

13.

Shaw G, Kamen R . A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell. 1986; 46(5):659-67. DOI: 10.1016/0092-8674(86)90341-7. View

14.

Warren M, Ralph P . Macrophage growth factor CSF-1 stimulates human monocyte production of interferon, tumor necrosis factor, and colony stimulating activity. J Immunol. 1986; 137(7):2281-5. View

15.

Horiguchi J, Warren M, Ralph P, Kufe D . Expression of the macrophage specific colony-stimulating factor (CSF-1) during human monocytic differentiation. Biochem Biophys Res Commun. 1986; 141(3):924-30. DOI: 10.1016/s0006-291x(86)80131-0. View

16.

Wong G, Temple P, Leary A, Yang Y, Ciarletta A, Chung M . Human CSF-1: molecular cloning and expression of 4-kb cDNA encoding the human urinary protein. Science. 1987; 235(4795):1504-8. DOI: 10.1126/science.3493529. View

17.

Horiguchi J, Warren M, Kufe D . Expression of the macrophage-specific colony-stimulating factor in human monocytes treated with granulocyte-macrophage colony-stimulating factor. Blood. 1987; 69(4):1259-61. View

18.

Rambaldi A, Young D, Griffin J . Expression of the M-CSF (CSF-1) gene by human monocytes. Blood. 1987; 69(5):1409-13. View

19.

OSTER W, Lindemann A, Horn S, Mertelsmann R, Herrmann F . Tumor necrosis factor (TNF)-alpha but not TNF-beta induces secretion of colony stimulating factor for macrophages (CSF-1) by human monocytes. Blood. 1987; 70(5):1700-3. View

20.

Wakamiya N, Horiguchi J, Kufe D . Detection of c-fms and CSF-1 RNA by in situ hybridization. Leukemia. 1987; 1(6):518-20. View