Expanded Roles for the MutL Family of DNA Mismatch Repair Proteins

Overview

Journal Yeast

Publisher Wiley

Specialty Microbiology

Date 2020 Jul 12

PMID 32652606

Citations 13

Authors

Christopher M Furman

Ryan Elbashir

Eric Alani

Affiliations

Soon will be listed here.

Abstract

The MutL family of DNA mismatch repair proteins plays a critical role in excising and repairing misincorporation errors during DNA replication. In many eukaryotes, members of this family have evolved to modulate and resolve recombination intermediates into crossovers during meiosis. In these organisms, such functions promote the accurate segregation of chromosomes during the meiosis I division. What alterations occurred in MutL homolog (MLH) family members that enabled them to acquire these new roles? In this review, we present evidence that the yeast Mlh1-Mlh3 and Mlh1-Mlh2 complexes have evolved novel enzymatic and nonenzymatic activities and protein-protein interactions that are critical for their meiotic functions. Curiously, even with these changes, these complexes retain backup and accessory roles in DNA mismatch repair during vegetative growth.

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