Spatial and Temporal Evolutionary Patterns in Puumala Orthohantavirus (PUUV) S Segment

Overview

Journal Pathogens

Date 2020 Jul 12

PMID 32650456

Citations 8

Authors

Florian Binder

Rene Ryll

Stephan Drewes

Sandra Jagdmann

Daniela Reil

Melanie Hiltbrunner

Ulrike M Rosenfeld

Christian Imholt

Jens Jacob

Gerald Heckel

Rainer G Ulrich

Affiliations

Soon will be listed here.

Abstract

The S segment of bank vole ()-associated Puumala orthohantavirus (PUUV) contains two overlapping open reading frames coding for the nucleocapsid (N) and a non-structural (NSs) protein. To identify the influence of bank vole population dynamics on PUUV S segment sequence evolution and test for spillover infections in sympatric rodent species, during 2010-2014, 883 bank voles, 357 yellow-necked mice (), 62 wood mice (), 149 common voles () and 8 field voles () were collected in Baden-Wuerttemberg and North Rhine-Westphalia, Germany. In total, 27.9% and 22.3% of bank voles were positive for PUUV-reactive antibodies and PUUV-specific RNA, respectively. One of eight field voles was PUUV RNA-positive, indicating a spillover infection, but none of the other species showed evidence of PUUV infection. Phylogenetic and isolation-by-distance analyses demonstrated a spatial clustering of PUUV S segment sequences. In the hantavirus outbreak years 2010 and 2012, PUUV RNA prevalence was higher in our study regions compared to non-outbreak years 2011, 2013 and 2014. NSs amino acid and nucleotide sequence types showed temporal and/or local variation, whereas the N protein was highly conserved in the NSs overlapping region and, to a lower rate, in the N alone coding part.

Citing Articles

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