Hepatic Mesenchymal Hamartoma and Undifferentiated Embryonal Sarcoma of the Liver: a Pathologic Review

Overview

Journal Hepat Oncol

Date 2020 Jul 11

PMID 32647564

Citations 19

Authors

Sebastiao N Martins-Filho

Juan Putra

Affiliations

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Abstract

This review highlights two rare entities that are predominantly seen in children: hepatic mesenchymal hamartoma (HMH) and undifferentiated embryonal sarcoma of the liver (UESL). HMH is a benign lesion predominantly seen in the first 2 years of life, while UESL is malignant and usually identified in patients between 6 and 10 years of age. UESL may arise in the background of HMH, and the association has been supported by similar chromosomal aberrations (19q13.4). The diagnosis of both lesions is primarily based on histologic evaluation, as the clinical and radiological features are not always typical. The clinicopathologic characteristics, pathogenesis, differential diagnoses and treatment for both lesions are discussed.

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References

Laberge J, Patenaude Y, Desilets V, Cartier L, Khalife S, Jutras L . Large hepatic mesenchymal hamartoma leading to mid-trimester fetal demise. Fetal Diagn Ther. 2005; 20(2):141-5. DOI: 10.1159/000082439. View

Zheng J, Tao X, Xu A, Chen X, Wu M, Zhang S . Primary and recurrent embryonal sarcoma of the liver: clinicopathological and immunohistochemical analysis. Histopathology. 2007; 51(2):195-203. DOI: 10.1111/j.1365-2559.2007.02746.x. View

Mathews J, Duncavage E, Pfeifer J . Characterization of translocations in mesenchymal hamartoma and undifferentiated embryonal sarcoma of the liver. Exp Mol Pathol. 2013; 95(3):319-24. DOI: 10.1016/j.yexmp.2013.09.006. View

Li Q, Wang J, Sun Y, Cui Y, Hao X . Hepatic angiosarcoma arising in an adult mesenchymal hamartoma. Int Semin Surg Oncol. 2007; 4:3. PMC: 1796548. DOI: 10.1186/1477-7800-4-3. View

Siddiqui M, McKenna B . Hepatic mesenchymal hamartoma: a short review. Arch Pathol Lab Med. 2006; 130(10):1567-9. DOI: 10.5858/2006-130-1567-HMHASR. View

Ng K, Mogul D . Pediatric Liver Tumors. Clin Liver Dis. 2018; 22(4):753-772. DOI: 10.1016/j.cld.2018.06.008. View

Sowery R, Jensen C, Morrison K, Horsman D, Sorensen P, Webber E . Comparative genomic hybridization detects multiple chromosomal amplifications and deletions in undifferentiated embryonal sarcoma of the liver. Cancer Genet Cytogenet. 2001; 126(2):128-33. DOI: 10.1016/s0165-4608(00)00404-0. View

Alwaidh M, Woodhall C, Carty H . Mesenchymal hamartoma of the liver: a case report. Pediatr Radiol. 1997; 27(3):247-9. DOI: 10.1007/s002470050113. View

Bejarano P, Serrano M, Casillas J, Dehner L, Kato T, Mitral N . Concurrent infantile hemangioendothelioma and mesenchymal hamartoma in a developmentally arrested liver of an infant requiring hepatic transplantation. Pediatr Dev Pathol. 2004; 6(6):552-7. DOI: 10.1007/s10024-003-3024-7. View

10.

Pan E, Yoeli D, Kueht M, Galvan N, Cotton R, OMahony C . Liver transplantation as definitive treatment of an unresectable mesenchymal hamartoma in a child with Beckwith-Wiedemann Syndrome. J Surg Case Rep. 2017; 2017(8):rjx167. PMC: 5597790. DOI: 10.1093/jscr/rjx167. View

11.

Bessho T, Kubota K, Komori S, Ohtsuka Y, Uneo Y, Uematsu K . Prenatally detected hepatic hamartoma: another cause of non-immune hydrops. Prenat Diagn. 1996; 16(4):337-41. DOI: 10.1002/(SICI)1097-0223(199604)16:4<337::AID-PD848>3.0.CO;2-U. View

12.

Cajaiba M, Sarita-Reyes C, Zambrano E, Reyes-Mugica M . Mesenchymal hamartoma of the liver associated with features of Beckwith-Wiedemann syndrome and high serum alpha-fetoprotein levels. Pediatr Dev Pathol. 2007; 10(3):233-8. DOI: 10.2350/06-07-0128.1. View

13.

Stocker J . Hepatic tumors in children. Clin Liver Dis. 2001; 5(1):259-81, viii-ix. DOI: 10.1016/s1089-3261(05)70163-x. View

14.

Shi M, Xu H, Sangster G, Gu X . Pulmonary Metastases from an Undifferentiated Embryonal Sarcoma of the Liver: A Case Report and Review. Case Rep Oncol Med. 2018; 2018:7840865. PMC: 6142750. DOI: 10.1155/2018/7840865. View

15.

Berte N, Filfilan A, Mainard L, Mansuy L, Lemelle J . Co-existing infantile hepatic hemangioma and mesenchymal hamartoma in a neonate. J Surg Case Rep. 2018; 2018(1):rjx260. PMC: 5786215. DOI: 10.1093/jscr/rjx260. View

16.

Pawoo N, Heller D . Placental mesenchymal dysplasia. Arch Pathol Lab Med. 2014; 138(9):1247-9. DOI: 10.5858/arpa.2013-0399-RS. View

17.

Beksac K, Mammadov R, Ciftci T, Guner G, Akyol A, Kaynaroglu V . Undifferentiated Embryonal Sarcoma of the Liver in an Adult Patient. Cureus. 2018; 10(7):e3037. PMC: 6153094. DOI: 10.7759/cureus.3037. View

18.

Putra J, Ornvold K . Undifferentiated embryonal sarcoma of the liver: a concise review. Arch Pathol Lab Med. 2015; 139(2):269-73. DOI: 10.5858/arpa.2013-0463-RS. View

19.

Kim J, Sio C, Park H, Kim H, Shin H, Jung K . Undifferentiated embryonal sarcoma of the liver in a child: A whole exome sequencing analysis. Dig Liver Dis. 2017; 49(8):944-946. DOI: 10.1016/j.dld.2017.04.020. View

20.

Thampy R, Elsayes K, Menias C, Pickhardt P, Kang H, Deshmukh S . Imaging features of rare mesenychmal liver tumours: beyond haemangiomas. Br J Radiol. 2017; 90(1079):20170373. PMC: 5963373. DOI: 10.1259/bjr.20170373. View