METTL3 Plays Multiple Functions in Biological Processes

Overview

Journal Am J Cancer Res

Specialty Oncology

Date 2020 Jul 10

PMID 32642280

Citations 89

Authors

Shuiping Liu

Lvjia Zhuo

Jianjun Wang

Qin Zhang

Qiujie Li

Guohua Li

Lili Yan

Ting Jin

Ting Pan

Xinbing Sui

Qun Lv

Tian Xie

Affiliations

Soon will be listed here.

Abstract

N-methyladenosine (mA) is the most common internal modification of mRNAs in higher eukaryotic. This process is performed by methyltransferase. Methyltransferase-like 3 (METTL3) is the best known mA methyltransferase that functions in the reversible epi-transcriptome modulation of mA modification. Besides acting as a mA methyltransferase, METTL3 also regulates mRNA translation and other biological processes. In recent years, studies have identified numerous roles and molecular mechanisms associated with METTL3 in multiple biological processes. However, these findings have not been summarized. In this review, we have systematically summarized the most recent important roles of METTL3 in various biological processes, including cell cycle progression, cell proliferation, cell apoptosis, cell migration and invasion, cell differentiation and inflammatory response. In addition, we discuss the prospect of using a METTL3 as a new diagnostic biomarker and therapeutic target for human cancers.

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