Effect of Autologous Adipose-derived Mesenchymal Stem Cell Therapy in the Treatment of an Osteochondral Lesion of the Ankle

Overview

Journal BMJ Case Rep

Specialty General Medicine

Date 2020 Jul 10

PMID 32641315

Citations 9

Authors

Julien Freitag

James Wickham

Kiran Shah

Abi Tenen

Affiliations

Soon will be listed here.

Abstract

Osteochondral lesions (OCLs) of the talus are rare but can be associated with significant morbidity and may lead to the development of osteoarthritis. An improved understanding of the action of mesenchymal stem cells (MSCs) has seen renewed interest in their role in cartilage repair, with early preclinical and clinical research showing benefits in symptomatic and structural improvement. A 42-year-old man presented with an unstable OCL of the talus and onset of early osteoarthritis with a history of multiple previous ankle arthroscopies for ankle impingement. The patient underwent arthroscopic removal of the OCL in combination with adipose-derived MSC therapy. The patient reported progressive improvement as measured by the validated Foot and Ankle Disability Index. Repeat MRI with additional T2 mapping techniques showed successful regeneration of hyaline-like cartilage. This case is the first to show the successful use of MSC therapy in the management of an ankle OCL. Trial registration: Australian New Zealand Clinical Trials Registry - ACTRN12617000638336.

Citing Articles

Adipose-derived mesenchymal stem cells combined with platelet-rich plasma are superior options for the treatment of osteoarthritis.

He W, Zhao J, Liu J, Wang F, Xu Z J Orthop Surg Res. 2025; 20(1):2.

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Mesenchymal stem cells in orthopaedics: A systematic review of applications to practice.

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Operative management of osteochondral lesions of the talus: 2024 recommendations of the working group 'clinical tissue regeneration' of the German Society of Orthopedics and Traumatology (DGOU).

Walther M, Gottschalk O, Aurich M EFORT Open Rev. 2024; 9(3):217-234.

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Adipose-derived stem cells applied to ankle pathologies: a systematic review.

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Contemporary Review: The Use of Adipocyte-Derived Mesenchymal Stem Cells in Pathologies of the Foot and Ankle.

Anastasio A, Bagheri K, Adams S Foot Ankle Orthop. 2023; 8(4):24730114231207643.

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