AIEgen-coupled Upconversion Nanoparticles Eradicate Solid Tumors Through Dual-mode ROS Activation

Overview

Journal Sci Adv

Specialties Biology
Science

Date 2020 Jul 9

PMID 32637621

Citations 32

Authors

Duo Mao

Fang Hu

Zhigao Yi

Kenry

Shidang Xu

Shuangqian Yan

Zichao Luo

Wenbo Wu

Zhihong Wang

Deling Kong

Xiaogang Liu

Bin Liu

Affiliations

Soon will be listed here.

Abstract

Reactive oxygen species (ROS) are essential for the regulation of antitumor immune responses, where they could induce immunogenic cell death, promote antigen presentation, and activate immune cells. Here, we report the development of near-infrared (NIR)-driven immunostimulants, based on coupling upconversion nanoparticles with aggregation-induced emission luminogens (AIEgens), to integrate the immunological effects of ROS for enhanced adaptive antitumor immune responses. Intratumorally injected AIEgen-upconversion nanoparticles produce high-dose ROS under high-power NIR irradiation, which induces immunogenic cell death and antigen release. These nanoparticles can also capture the released antigens and deliver them to lymph nodes. Upon subsequent low-power NIR treatment of lymph nodes, low-dose ROS are generated to further trigger efficient T cell immune responses through activation of dendritic cells, preventing both local tumor recurrence and distant tumor growth. The utility of dual-mode pumping power on AIEgen-coupled upconversion nanoparticles offers a powerful and controllable platform to activate adaptive immune systems for tumor immunotherapy.

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