Chemorefractory Liver Metastasis from Cervical Cancer Successfully Treated with a Combination of Yttrium-90 and Immunotherapy

Overview

Journal Radiol Case Rep

Publisher Elsevier

Specialty Radiology

Date 2020 Jul 9

PMID 32636973

Citations 5

Authors

Michael E Nance

Gregory B Biedermann

Ambarish P Bhat

Ryan M Davis

Affiliations

Soon will be listed here.

Abstract

Liver metastases in cervical cancer is rare and can be difficult-to-treat. The current guidelines established by the Gynecologic Oncology Group recommend platinum-based systemic chemotherapy in combination with an anti-angiogenic agent such as bevacizumab, however, overall survival remains poor following diagnosis and options for patients who fail chemotherapy are limited. Yttrium-90 (Y90) radioembolization (RE) has shown great promise in the treatment of chemo-refractory colorectal liver metastases. We describe a 30-year-old female with a history of stage IB endocervical adenocarcinoma who later developed metastases to the liver, that were unresponsive to multiple chemotherapeutics and chemoembolization, and was successfully treated with Y90 RE with concurrent systemic Pembrolizumab. The Y90 RE treatment resulted in positive clinical and imaging responses with improvement in her quality of life, all of which continue to persist at the time of writing this manuscript about 8-months into her RE treatment.

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