Could Protons and Carbon Ions Be the Silver Bullets Against Pancreatic Cancer?

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2020 Jul 9

PMID 32635552

Citations 5

Authors

Camille Huart

Jia-Wei Chen

Benjamin Le Calve

Carine Michiels

Anne-Catherine Wera

Affiliations

Soon will be listed here.

Abstract

Pancreatic cancer is a very aggressive cancer type associated with one of the poorest prognostics. Despite several clinical trials to combine different types of therapies, none of them resulted in significant improvements for patient survival. Pancreatic cancers demonstrate a very broad panel of resistance mechanisms due to their biological properties but also their ability to remodel the tumour microenvironment. Radiotherapy is one of the most widely used treatments against cancer but, up to now, its impact remains limited in the context of pancreatic cancer. The modern era of radiotherapy proposes new approaches with increasing conformation but also more efficient effects on tumours in the case of charged particles. In this review, we highlight the interest in using charged particles in the context of pancreatic cancer therapy and the impact of this alternative to counteract resistance mechanisms.

Citing Articles

High-LET charged particles: radiobiology and application for new approaches in radiotherapy.

Helm A, Fournier C Strahlenther Onkol. 2023; 199(12):1225-1241.

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Physics and biomedical challenges of cancer therapy with accelerated heavy ions.

Durante M, Debus J, Loeffler J Nat Rev Phys. 2021; 3(12):777-790.

PMID: 34870097 PMC: 7612063. DOI: 10.1038/s42254-021-00368-5.

Updates and new directions in the use of radiation therapy for the treatment of pancreatic adenocarcinoma: dose, sensitization, and novel technology.

Hall W, Kamgar M, Erickson B, Beltran Ponce S, Tsai S, Nevalainen M Cancer Metastasis Rev. 2021; 40(3):879-889.

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Magnetic Resonance Guided Radiation Therapy for Pancreatic Adenocarcinoma, Advantages, Challenges, Current Approaches, and Future Directions.

Hall W, Small C, Paulson E, Koay E, Crane C, Intven M Front Oncol. 2021; 11:628155.

PMID: 34046339 PMC: 8144850. DOI: 10.3389/fonc.2021.628155.

Carbon Ion Radiobiology.

Tinganelli W, Durante M Cancers (Basel). 2020; 12(10).

PMID: 33080914 PMC: 7603235. DOI: 10.3390/cancers12103022.

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