Enhanced Salivary and General Oxidative Stress in Hashimoto's Thyroiditis Women in Euthyreosis

Overview

Journal J Clin Med

Specialty General Medicine

Date 2020 Jul 9

PMID 32635382

Citations 16

Authors

Katarzyna Morawska

Mateusz Maciejczyk

Lukasz Poplawski

Anna Poplawska-Kita

Adam Kretowski

Anna Zalewska

Affiliations

Soon will be listed here.

Abstract

Hashimoto's thyroiditis (HT) is one of the most common autoimmune diseases. Although HT is inextricably linked to oxidative stress, there have been no studies assessing salivary redox homeostasis or salivary gland function in patients with HT. This study is the first to compare antioxidant defense and oxidative stress biomarkers in non-stimulated (NWS) and stimulated (SWS) whole saliva and plasma/erythrocytes of HT patients compared to controls. The study included 45 women with HT in the euthyreosis period as well as an age- and gender-matched control group. We showed that NWS secretion was significantly lower in HT patients compared to healthy controls, similar to salivary amylase activity in NWS and SWS. Catalase and peroxidase activities were considerably higher in NWS and SWS of HT patients, while the concentrations of reduced glutathione and uric acid were significantly lower in comparison with healthy subjects. Total antioxidant potential was significantly lower, while total oxidant status and the level of oxidation products of proteins (advanced glycation end products, advanced oxidation protein products) and lipids (malondialdehyde, lipid hydroperoxides) were significantly higher in NWS, SWS and plasma of HT patients. In conclusion, in both salivary glands of women with HT in euthyreosis, the ability to maintain redox homeostasis was hindered. In HT patients we observed oxidative damage to salivary proteins and lipids; thus, some biomarkers of oxidative stress may present a potential diagnostic value.

Citing Articles

Salivary Alterations in Autoimmune Thyroid Diseases: A Systematic Review.

Ortarzewska M, Nijakowski K, Kolasinska J, Gruszczynski D, Ruchala M, Lehmann A Int J Environ Res Public Health. 2023; 20(6).

PMID: 36981758 PMC: 10048832. DOI: 10.3390/ijerph20064849.

The NF-κB pathway plays a vital role in rat salivary gland atrophy model.

Yang Y, Zi Y, Conglin D, Chunmei Z, Liang H, Songlin W Heliyon. 2023; 9(3):e14288.

PMID: 36950625 PMC: 10025116. DOI: 10.1016/j.heliyon.2023.e14288.

Changes in biomarkers of redox status in serum and saliva of dogs with hypothyroidism.

Arostegui L, Prieto A, Pardo Marin L, Lopez G, Tvarijonaviciute A, Ceron Madrigal J BMC Vet Res. 2023; 19(1):33.

PMID: 36732758 PMC: 9896751. DOI: 10.1186/s12917-023-03586-4.

N-acetylcysteine regulates dental follicle stem cell osteogenesis and alveolar bone repair via ROS scavenging.

Meng Z, Liu J, Feng Z, Guo S, Wang M, Wang Z Stem Cell Res Ther. 2022; 13(1):466.

PMID: 36076278 PMC: 9461171. DOI: 10.1186/s13287-022-03161-y.

Emerging trends and hot spots in autoimmune thyroiditis research from 2000 to 2022: A bibliometric analysis.

Li Q, Yang W, Li J, Shan Z Front Immunol. 2022; 13:953465.

PMID: 36032148 PMC: 9402901. DOI: 10.3389/fimmu.2022.953465.

References

Knas M, Maciejczyk M, Sawicka K, Hady H, Niczyporuk M, Ladny J . Impact of morbid obesity and bariatric surgery on antioxidant/oxidant balance of the unstimulated and stimulated human saliva. J Oral Pathol Med. 2015; 45(6):455-64. DOI: 10.1111/jop.12383. View

Grintzalis K, Zisimopoulos D, Grune T, Weber D, Georgiou C . Method for the simultaneous determination of free/protein malondialdehyde and lipid/protein hydroperoxides. Free Radic Biol Med. 2012; 59:27-35. DOI: 10.1016/j.freeradbiomed.2012.09.038. View

Su H, Baron M, Benarroch M, Velly A, Gravel S, Schipper H . Altered salivary redox homeostasis in patients with systemic sclerosis. J Rheumatol. 2010; 37(9):1858-63. DOI: 10.3899/jrheum.091451. View

Hanstrom L, Johansson A, Carlsson J . Lactoperoxidase and thiocyanate protect cultured mammalian cells against hydrogen peroxide toxicity. Med Biol. 1983; 61(5):268-74. View

Lushchak V . Glutathione homeostasis and functions: potential targets for medical interventions. J Amino Acids. 2012; 2012:736837. PMC: 3303626. DOI: 10.1155/2012/736837. View

Azuma M, Aota K, Tamatani T, Motegi K, Yamashita T, Ashida Y . Suppression of tumor necrosis factor alpha-induced matrix metalloproteinase 9 production in human salivary gland acinar cells by cepharanthine occurs via down-regulation of nuclear factor kappaB: a possible therapeutic agent for preventing the.... Arthritis Rheum. 2002; 46(6):1585-94. DOI: 10.1002/art.10315. View

Darczuk D, Krzysciak W, Bystrowska B, Kesek B, Koscielniak D, Chomyszyn-Gajewska M . The Relationship between the Concentration of Salivary Tyrosine and Antioxidants in Patients with Oral Lichen Planus. Oxid Med Cell Longev. 2019; 2019:5801570. PMC: 6906868. DOI: 10.1155/2019/5801570. View

Bozzato A, Burger P, Zenk J, Uter W, Iro H . Salivary gland biometry in female patients with eating disorders. Eur Arch Otorhinolaryngol. 2008; 265(9):1095-102. DOI: 10.1007/s00405-008-0598-8. View

Matczuk J, Zendzian-Piotrowska M, Maciejczyk M, Kurek K . Salivary lipids: A review. Adv Clin Exp Med. 2017; 26(6):1021-1029. DOI: 10.17219/acem/63030. View

10.

Buege J, Aust S . Microsomal lipid peroxidation. Methods Enzymol. 1978; 52:302-10. DOI: 10.1016/s0076-6879(78)52032-6. View

11.

Babiuch K, Bednarczyk A, Gawlik K, Pawlica-Gosiewska D, Kesek B, Darczuk D . Evaluation of enzymatic and non-enzymatic antioxidant status and biomarkers of oxidative stress in saliva of patients with oral squamous cell carcinoma and oral leukoplakia: a pilot study. Acta Odontol Scand. 2019; 77(6):408-418. DOI: 10.1080/00016357.2019.1578409. View

12.

Zalewska A, Knas M, Waszkiewicz N, Waszkiel D, Sierakowski S, Zwierz K . Rheumatoid arthritis patients with xerostomia have reduced production of key salivary constituents. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013; 115(4):483-90. DOI: 10.1016/j.oooo.2012.10.013. View

13.

Kolodziej U, Maciejczyk M, Niklinska W, Waszkiel D, Zendzian-Piotrowska M, Zukowski P . Chronic high-protein diet induces oxidative stress and alters the salivary gland function in rats. Arch Oral Biol. 2017; 84:6-12. DOI: 10.1016/j.archoralbio.2017.09.006. View

14.

Paglia D, Valentine W . Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med. 1967; 70(1):158-69. View

15.

Burek C, Rose N . Autoimmune thyroiditis and ROS. Autoimmun Rev. 2008; 7(7):530-7. DOI: 10.1016/j.autrev.2008.04.006. View

16.

Kalousova M, Skrha J, Zima T . Advanced glycation end-products and advanced oxidation protein products in patients with diabetes mellitus. Physiol Res. 2003; 51(6):597-604. View

17.

Skutnik-Radziszewska A, Maciejczyk M, Flisiak I, Kolodziej J, Kotowska-Rodziewicz A, Klimiuk A . Enhanced Inflammation and Nitrosative Stress in the Saliva and Plasma of Patients with Plaque Psoriasis. J Clin Med. 2020; 9(3). PMC: 7141316. DOI: 10.3390/jcm9030745. View

18.

Duthoit C, Estienne V, Giraud A, Rasmussen A, Feldt-Rasmussen U, Carayon P . Hydrogen peroxide-induced production of a 40 kDa immunoreactive thyroglobulin fragment in human thyroid cells: the onset of thyroid autoimmunity?. Biochem J. 2001; 360(Pt 3):557-62. PMC: 1222257. DOI: 10.1042/0264-6021:3600557. View

19.

Skutnik-Radziszewska A, Maciejczyk M, Fejfer K, Krahel J, Flisiak I, Kolodziej U . Salivary Antioxidants and Oxidative Stress in Psoriatic Patients: Can Salivary Total Oxidant Status and Oxidative Status Index Be a Plaque Psoriasis Biomarker?. Oxid Med Cell Longev. 2020; 2020:9086024. PMC: 6964728. DOI: 10.1155/2020/9086024. View

20.

Erel O . A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin Biochem. 2004; 37(4):277-85. DOI: 10.1016/j.clinbiochem.2003.11.015. View