Role of Peroxiredoxins in Protecting Against Cardiovascular and Related Disorders

Overview

Journal Cardiovasc Toxicol

Specialties Cardiology & Vascular Diseases
Toxicology

Date 2020 Jul 8

PMID 32632849

Citations 9

Authors

Y Robert Li

Hong Zhu

Igor Danelisen

Affiliations

Soon will be listed here.

Abstract

Peroxiredoxin (Prx) refers to a family of thiol-dependent peroxidases that decompose hydrogen peroxide, lipid hydroperoxides, as well as peroxynitrite, and protect against oxidative and inflammatory stress. There are six mammalian Prx isozymes (Prx1-6), classified as typical 2-Cys, atypical 2-Cys, or 1-Cys Prxs based on the mechanism and the number of cysteine residues involved during catalysis. In addition to their well-established peroxide-scavenging activity, some Prxs also participate in the regulation of various cell signaling pathways. Extensive animal studies employing primarily gene knockout models provide substantial evidence supporting a critical protective role of Prxs in various disease processes involving oxidative and inflammatory stress. This review surveys recent research findings, published primarily in influential journals, on the involvement of various Prx isozymes in protecting against cardiovascular injury and related disorders, including diabetes, metabolic syndromes, and sepsis, whose pathophysiology all intimately involves oxidative stress and inflammation.

Citing Articles

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References

Kim K, Kim I, Lee K, Rhee S, Stadtman E . The isolation and purification of a specific "protector" protein which inhibits enzyme inactivation by a thiol/Fe(III)/O2 mixed-function oxidation system. J Biol Chem. 1988; 263(10):4704-11. View

Salzano S, Checconi P, Hanschmann E, Lillig C, Bowler L, Chan P . Linkage of inflammation and oxidative stress via release of glutathionylated peroxiredoxin-2, which acts as a danger signal. Proc Natl Acad Sci U S A. 2014; 111(33):12157-62. PMC: 4143057. DOI: 10.1073/pnas.1401712111. View

Bryk R, Griffin P, Nathan C . Peroxynitrite reductase activity of bacterial peroxiredoxins. Nature. 2000; 407(6801):211-5. DOI: 10.1038/35025109. View

Manta B, Hugo M, Ortiz C, Ferrer-Sueta G, Trujillo M, Denicola A . The peroxidase and peroxynitrite reductase activity of human erythrocyte peroxiredoxin 2. Arch Biochem Biophys. 2008; 484(2):146-54. DOI: 10.1016/j.abb.2008.11.017. View

De Armas M, Esteves R, Viera N, Reyes A, Mastrogiovanni M, Alegria T . Rapid peroxynitrite reduction by human peroxiredoxin 3: Implications for the fate of oxidants in mitochondria. Free Radic Biol Med. 2018; 130:369-378. DOI: 10.1016/j.freeradbiomed.2018.10.451. View

Chen J, Dodia C, Feinstein S, Jain M, Fisher A . 1-Cys peroxiredoxin, a bifunctional enzyme with glutathione peroxidase and phospholipase A2 activities. J Biol Chem. 2000; 275(37):28421-7. DOI: 10.1074/jbc.M005073200. View

Kisucka J, Chauhan A, Patten I, Yesilaltay A, Neumann C, Van Etten R . Peroxiredoxin1 prevents excessive endothelial activation and early atherosclerosis. Circ Res. 2008; 103(6):598-605. PMC: 4911701. DOI: 10.1161/CIRCRESAHA.108.174870. View

Jeong S, Kim S, Park J, Jung I, Lee M, Jeon S . Prdx1 (peroxiredoxin 1) deficiency reduces cholesterol efflux via impaired macrophage lipophagic flux. Autophagy. 2017; 14(1):120-133. PMC: 5846566. DOI: 10.1080/15548627.2017.1327942. View

Stancill J, Happ J, Broniowska K, Hogg N, Corbett J . Peroxiredoxin 1 plays a primary role in protecting pancreatic β-cells from hydrogen peroxide and peroxynitrite. Am J Physiol Regul Integr Comp Physiol. 2020; 318(5):R1004-R1013. PMC: 7272767. DOI: 10.1152/ajpregu.00011.2020. View

10.

Wang Q, Cai Y, Tian D, Yang H, Wei Z, Wang F . Peroxiredoxin1: a potential obesity-related factor in the hypothalamus. Med Sci Monit. 2010; 16(10):BR321-6. View

11.

Choi M, Lee I, Kim G, Kim B, Han Y, Yu D . Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II. Nature. 2005; 435(7040):347-53. DOI: 10.1038/nature03587. View

12.

Sundaresan M, Yu Z, Ferrans V, Irani K, Finkel T . Requirement for generation of H2O2 for platelet-derived growth factor signal transduction. Science. 1995; 270(5234):296-9. DOI: 10.1126/science.270.5234.296. View

13.

He C, Medley S, Hu T, Hinsdale M, Lupu F, Virmani R . PDGFRβ signalling regulates local inflammation and synergizes with hypercholesterolaemia to promote atherosclerosis. Nat Commun. 2015; 6:7770. PMC: 4507293. DOI: 10.1038/ncomms8770. View

14.

Park J, Yoo J, Jeong S, Choi J, Lee M, Lee M . Peroxiredoxin 2 deficiency exacerbates atherosclerosis in apolipoprotein E-deficient mice. Circ Res. 2011; 109(7):739-49. PMC: 5474748. DOI: 10.1161/CIRCRESAHA.111.245530. View

15.

Jang J, Wang S, Min J, Chae Y, Baek J, Yu D . Peroxiredoxin II is an antioxidant enzyme that negatively regulates collagen-stimulated platelet function. J Biol Chem. 2015; 290(18):11432-42. PMC: 4416848. DOI: 10.1074/jbc.M115.644260. View

16.

Federti E, Matte A, Ghigo A, Andolfo I, James C, Siciliano A . Peroxiredoxin-2 plays a pivotal role as multimodal cytoprotector in the early phase of pulmonary hypertension. Free Radic Biol Med. 2017; 112:376-386. DOI: 10.1016/j.freeradbiomed.2017.08.004. View

17.

Kang S, Chang T, Lee T, Kim E, Yu D, Rhee S . Cytosolic peroxiredoxin attenuates the activation of Jnk and p38 but potentiates that of Erk in Hela cells stimulated with tumor necrosis factor-alpha. J Biol Chem. 2003; 279(4):2535-43. DOI: 10.1074/jbc.M307698200. View

18.

Yang C, Lee D, Song C, An S, Li S, Kim J . Roles of peroxiredoxin II in the regulation of proinflammatory responses to LPS and protection against endotoxin-induced lethal shock. J Exp Med. 2007; 204(3):583-94. PMC: 2137909. DOI: 10.1084/jem.20061849. View

19.

Matsushima S, Ide T, Yamato M, Matsusaka H, Hattori F, Ikeuchi M . Overexpression of mitochondrial peroxiredoxin-3 prevents left ventricular remodeling and failure after myocardial infarction in mice. Circulation. 2006; 113(14):1779-86. DOI: 10.1161/CIRCULATIONAHA.105.582239. View

20.

Tsutsui H, Kinugawa S, Matsushima S . Mitochondrial oxidative stress and dysfunction in myocardial remodelling. Cardiovasc Res. 2008; 81(3):449-56. DOI: 10.1093/cvr/cvn280. View