Applications of Bacillus Subtilis Spores in Biotechnology and Advanced Materials

Overview

Journal Appl Environ Microbiol

Specialties Environmental Health
Microbiology

Date 2020 Jul 8

PMID 32631858

Citations 19

Authors

Xiaopei Zhang

Amal Al-Dossary

Myer Hussain

Peter Setlow

Jiahe Li

Affiliations

Soon will be listed here.

Abstract

The bacterium has long been an important subject for basic studies. However, this organism has also had industrial applications due to its easy genetic manipulation, favorable culturing characteristics for large-scale fermentation, superior capacity for protein secretion, and generally recognized as safe (GRAS) status. In addition, as the metabolically dormant form of , its spores have attracted great interest due to their extreme resistance to many environmental stresses, which makes spores a novel platform for a variety of applications. In this review, we summarize both conventional and emerging applications of spores, with a focus on how their unique characteristics have led to innovative applications in many areas of technology, including generation of stable and recyclable enzymes, synthetic biology, drug delivery, and material sciences. Ultimately, this review hopes to inspire the scientific community to leverage interdisciplinary approaches using spores to address global concerns about food shortages, environmental protection, and health care.

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