The Effectiveness of Probiotics in the Treatment of Inflammatory Bowel Disease (IBD)-A Critical Review

Overview

Journal Nutrients

Date 2020 Jul 8

PMID 32630805

Citations 104

Authors

Dominika Jakubczyk

Katarzyna Leszczynska

Sabina Gorska

Affiliations

Soon will be listed here.

Abstract

Inflammatory bowel disease (IBD), which affects millions of people worldwide, includes two separate diseases: Crohn's disease (CD) and ulcerative colitis (UC). Although the background (chronic inflammatory state) and some of the symptoms of CD and UC are similar, both diseases differ from each other. It is becoming clear that a combination of many factors, in particular genetic background, host immune response and microbial reduced diversity status are associated with IBD. One potential strategy to prevent/treat IBD is gut modulation by probiotics. Over the last twenty years, many publications have focused on the role of probiotics in the course of IBD. The review discusses the utility of different strains of probiotics, especially spp., in all factors potentially involved in the etiology of IBD. The probiotic modulatory properties among different study models (cell lines, animal models of colitis, clinical study) are discussed and probiotic usefulness is assessed in relation to the treatment, prevention, and remission of diseases.

Citing Articles

Impact of Li01 on benzo[]pyrene-induced colitis, based on host-microbiome interactions in Mongolian gerbils.

Huang Y, Yang C, Fu B, Guo H, Chen Y, Xu D Front Nutr. 2025; 12:1494525.

PMID: 40078411 PMC: 11896860. DOI: 10.3389/fnut.2025.1494525.

Impact of Vitamins, Antibiotics, Probiotics, and History of COVID-19 on the Gut Microbiome in Ulcerative Colitis Patients: A Cross-Sectional Study.

Straume Z, Krumina N, Elbere I, Rozenberga M, Erts R, Rudzite D Medicina (Kaunas). 2025; 61(2).

PMID: 40005401 PMC: 11857389. DOI: 10.3390/medicina61020284.

Prebiotic selection influencing inflammatory bowel disease treatment outcomes: a review of the preclinical and clinical evidence.

Ariaee A, Koentgen S, Wardill H, Hold G, Prestidge C, Armstrong H eGastroenterology. 2025; 2(2):e100055.

PMID: 39944472 PMC: 11731074. DOI: 10.1136/egastro-2023-100055.

Interrelationships of the Intestinal Microbiome, Trimethylamine N-Oxide and Lipopolysaccharide-Binding Protein with Crohn's Disease Activity.

Laryushina Y, Samoilova-Bedych N, Turgunova L, Marchenko A, Turgunov Y, Kozhakhmetov S Pathogens. 2025; 14(1).

PMID: 39860966 PMC: 11768583. DOI: 10.3390/pathogens14010005.

Importance of Lactobacilli for Human Health.

Heczko P, Giemza M, Ponikiewska W, Strus M Microorganisms. 2025; 12(12.

PMID: 39770585 PMC: 11676770. DOI: 10.3390/microorganisms12122382.

References

Li J, Ueno A, Fort Gasia M, Luider J, Wang T, Hirota C . Profiles of Lamina Propria T Helper Cell Subsets Discriminate Between Ulcerative Colitis and Crohn's Disease. Inflamm Bowel Dis. 2016; 22(8):1779-92. DOI: 10.1097/MIB.0000000000000811. View

Liu J, van Sommeren S, Huang H, Ng S, Alberts R, Takahashi A . Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations. Nat Genet. 2015; 47(9):979-986. PMC: 4881818. DOI: 10.1038/ng.3359. View

Alex P, Zachos N, Nguyen T, Gonzales L, Chen T, Conklin L . Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBS-induced colitis. Inflamm Bowel Dis. 2008; 15(3):341-52. PMC: 2643312. DOI: 10.1002/ibd.20753. View

Zakostelska Z, Kverka M, Klimesova K, Rossmann P, Mrazek J, Kopecny J . Lysate of probiotic Lactobacillus casei DN-114 001 ameliorates colitis by strengthening the gut barrier function and changing the gut microenvironment. PLoS One. 2011; 6(11):e27961. PMC: 3222668. DOI: 10.1371/journal.pone.0027961. View

Lim M, Wallace M . Infectious diarrhea in history. Infect Dis Clin North Am. 2004; 18(2):261-74. DOI: 10.1016/j.idc.2004.01.006. View

Ogawa A, Andoh A, Araki Y, Bamba T, Fujiyama Y . Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice. Clin Immunol. 2004; 110(1):55-62. DOI: 10.1016/j.clim.2003.09.013. View

Ramanan D, Bowcutt R, Lee S, Tang M, Kurtz Z, Ding Y . Helminth infection promotes colonization resistance via type 2 immunity. Science. 2016; 352(6285):608-12. PMC: 4905769. DOI: 10.1126/science.aaf3229. View

Jostins L, Ripke S, Weersma R, Duerr R, McGovern D, Hui K . Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature. 2012; 491(7422):119-24. PMC: 3491803. DOI: 10.1038/nature11582. View

Nagy Z, Karadi O, Rumi G, Rumi Jr G, Par A, Mozsik G . Crohn's disease is associated with polymorphism of CARD15/NOD2 gene in a Hungarian population. Ann N Y Acad Sci. 2005; 1051:45-51. DOI: 10.1196/annals.1361.045. View

10.

Reid G, Bruce A, Fraser N, Heinemann C, Owen J, Henning B . Oral probiotics can resolve urogenital infections. FEMS Immunol Med Microbiol. 2001; 30(1):49-52. DOI: 10.1111/j.1574-695X.2001.tb01549.x. View

11.

Eastaff-Leung N, Mabarrack N, Barbour A, Cummins A, Barry S . Foxp3+ regulatory T cells, Th17 effector cells, and cytokine environment in inflammatory bowel disease. J Clin Immunol. 2009; 30(1):80-9. DOI: 10.1007/s10875-009-9345-1. View

12.

Javed N, Alsahly M, Khubchandani J . Oral Feeding of Probiotic Bifidobacterium infantis: Colonic Morphological Changes in Rat Model of TNBS-Induced Colitis. Scientifica (Cairo). 2016; 2016:9572596. PMC: 4834163. DOI: 10.1155/2016/9572596. View

13.

Rodemann J, Dubberke E, Reske K, Seo D, Stone C . Incidence of Clostridium difficile infection in inflammatory bowel disease. Clin Gastroenterol Hepatol. 2007; 5(3):339-44. DOI: 10.1016/j.cgh.2006.12.027. View

14.

Chassaing B, Aitken J, Malleshappa M, Vijay-Kumar M . Dextran sulfate sodium (DSS)-induced colitis in mice. Curr Protoc Immunol. 2014; 104:15.25.1-15.25.14. PMC: 3980572. DOI: 10.1002/0471142735.im1525s104. View

15.

Niewiadomski O, Studd C, Wilson J, Williams J, Hair C, Knight R . Influence of food and lifestyle on the risk of developing inflammatory bowel disease. Intern Med J. 2016; 46(6):669-76. DOI: 10.1111/imj.13094. View

16.

Fedorak R, Feagan B, Hotte N, Leddin D, Dieleman L, Petrunia D . The probiotic VSL#3 has anti-inflammatory effects and could reduce endoscopic recurrence after surgery for Crohn's disease. Clin Gastroenterol Hepatol. 2014; 13(5):928-35.e2. DOI: 10.1016/j.cgh.2014.10.031. View

17.

Rocha C, Lakhdari O, Blottiere H, Blugeon S, Sokol H, Bermudez-Humaran L . Anti-inflammatory properties of dairy lactobacilli. Inflamm Bowel Dis. 2011; 18(4):657-66. DOI: 10.1002/ibd.21834. View

18.

Martignoni M, Groothuis G, de Kanter R . Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction. Expert Opin Drug Metab Toxicol. 2006; 2(6):875-94. DOI: 10.1517/17425255.2.6.875. View

19.

Kowalska-Duplaga K, Gosiewski T, Kapusta P, Sroka-Oleksiak A, Wedrychowicz A, Pieczarkowski S . Differences in the intestinal microbiome of healthy children and patients with newly diagnosed Crohn's disease. Sci Rep. 2019; 9(1):18880. PMC: 6906406. DOI: 10.1038/s41598-019-55290-9. View

20.

Bassaganya-Riera J, Viladomiu M, Pedragosa M, De Simone C, Hontecillas R . Immunoregulatory mechanisms underlying prevention of colitis-associated colorectal cancer by probiotic bacteria. PLoS One. 2012; 7(4):e34676. PMC: 3325233. DOI: 10.1371/journal.pone.0034676. View