Relationship Between Plasma Total Homocysteine and the Severity of Renal Function in Chinese Patients with Type 2 Diabetes Mellitus Aged ≥75 Years

Overview

Journal Medicine (Baltimore)

Specialty General Medicine

Date 2020 Jul 8

PMID 32629650

Citations 5

Authors

Ning Ma

Ning Xu

Dong Yin

Weiwei Liu

Mengping Wu

Xingbo Cheng

Affiliations

Soon will be listed here.

Abstract

We aimed to investigate the relationship between total homocysteine (tHcy) levels in the plasma and renal function severity in patients with type 2 diabetes mellitus (T2DM) aged ≥75 years.We included 221 patients with T2DM aged ≥60 years (59 aged ≥75 years).tHcy levels among the 4 groups of patients aged ≥60 years significantly differed, but not in those aged ≥75 years. tHcy levels in patients aged ≥60 years were negatively correlated with the estimated glomerular filtration rate. The area under the receiver operating characteristic curve of tHcy for predicting diabetic kidney disease (DKD) was 0.636. Fasting c-peptide and creatinine were independently associated with tHcy levels in patients aged ≥60 years, whereas insulin and creatinine were independently associated with tHcy levels in those aged ≥75 years.tHcy concentrations were elevated in T2DM and can potentially serve as a risk factor for DKD, but it is not an ideal biomarker.

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