DC-potential Shifts and Regional Cerebral Blood Flow Reveal Frontal Cortex Involvement in Human Visuomotor Learning

Overview

Journal Exp Brain Res

Specialty Neurology

Date 1988 Jan 1

PMID 3262531

Citations 15

Authors

W Lang

M Lang

I Podreka

M Steiner

F Uhl

E Suess

C Muller

L Deecke

Affiliations

Soon will be listed here.

Abstract

In the present study, two different physiological parameters were measured to describe brain activity related to visuomotor learning: performance-related DC-potential shifts and regional cerebral blood flow (rCBF) by Tc-99m HMPAO brain SPECT (Single Photon Emission Computerized Tomography). Visuomotor learning was required in a conflicting situation: a visual target moved on a screen and had to be tracked by moving the right hand in an inverted fashion (IT), e.g. movements of the target to the right side required hand movement to the left and vice versa. Compared to a normal, non-inverted control task (T), IT required the development of a novel motor program and the prevention of returning to routine direct pursuit. These additional demands in IT caused a relative hyperperfusion in regions including the middle frontal gyri, frontomedial cortex (including the supplementary motor area, SMA), right basal ganglia (caudate-putamen) and left cerebellum. Correlations of rCBF values between the middle frontal gyrus and basal ganglia may indicate a functional relation between these two brain structures. Visuomotor performance was accompanied by slow negative DC-potential shifts. In frontal and to a lesser degree in central recordings, amplitudes of DC-negativity were larger in IT than they were in T. This additional frontal negativity covaried with the success of learning. Results substantiate, now using a dual approach, previous suggestions that the frontal lobe plays an important role in visuomotor learning.

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References

Frith C, Bloxham C, Carpenter K . Impairments in the learning and performance of a new manual skill in patients with Parkinson's disease. J Neurol Neurosurg Psychiatry. 1986; 49(6):661-8. PMC: 1028849. DOI: 10.1136/jnnp.49.6.661. View

Halsband U, Passingham R . Premotor cortex and the conditions for movement in monkeys (Macaca fascicularis). Behav Brain Res. 1985; 18(3):269-77. DOI: 10.1016/0166-4328(85)90035-x. View

Godschalk M, Lemon R, Kuypers H, van der Steen J . The involvement of monkey premotor cortex neurones in preparation of visually cued arm movements. Behav Brain Res. 1985; 18(2):143-57. DOI: 10.1016/0166-4328(85)90070-1. View

Goldenberg G, Podreka I, Steiner M, Willmes K . Patterns of regional cerebral blood flow related to memorizing of high and low imagery words--an emission computer tomography study. Neuropsychologia. 1987; 25(3):473-85. DOI: 10.1016/0028-3932(87)90072-8. View

Lang W, Lang M, Kornhuber A, Deecke L, Kornhuber H . Human cerebral potentials and visuomotor learning. Pflugers Arch. 1983; 399(4):342-4. DOI: 10.1007/BF00652762. View

Neirinckx R, Canning L, Piper I, Nowotnik D, PICKETT R, Holmes R . Technetium-99m d,l-HM-PAO: a new radiopharmaceutical for SPECT imaging of regional cerebral blood perfusion. J Nucl Med. 1987; 28(2):191-202. View

Rizzolatti G, Matelli M, Pavesi G . Deficits in attention and movement following the removal of postarcuate (area 6) and prearcuate (area 8) cortex in macaque monkeys. Brain. 1983; 106 (Pt 3):655-73. DOI: 10.1093/brain/106.3.655. View

Kubota K, Hamada I . Visual tracking and neuron activity in the post-arcuate area in monkeys. J Physiol (Paris). 1978; 74(3):297-312. View

Lang W, Lang M, Goldenberg G, Podreka I, Deecke L . EEG and rCBF evidence for left frontocortical activation when memorizing verbal material. Electroencephalogr Clin Neurophysiol Suppl. 1987; 40:328-34. View

10.

Podreka I, Suess E, Goldenberg G, Steiner M, Brucke T, Muller C . Initial experience with technetium-99m HM-PAO brain SPECT. J Nucl Med. 1987; 28(11):1657-66. View

11.

ALLEN G, Tsukahara N . Cerebrocerebellar communication systems. Physiol Rev. 1974; 54(4):957-1006. DOI: 10.1152/physrev.1974.54.4.957. View

12.

Sasaki K, Gemba H, Mizuno N . Cortical field potentials preceding visually initiated hand movements and cerebellar actions in the monkey. Exp Brain Res. 1982; 46(1):29-36. DOI: 10.1007/BF00238095. View

13.

Passingham R . Premotor cortex: sensory cues and movement. Behav Brain Res. 1985; 18(2):175-85. DOI: 10.1016/0166-4328(85)90073-7. View

14.

Kemp J, Powell T . The cortico-striate projection in the monkey. Brain. 1970; 93(3):525-46. DOI: 10.1093/brain/93.3.525. View

15.

Sams M, Hamalainen M, Antervo A, Kaukoranta E, Reinikainen K, Hari R . Cerebral neuromagnetic responses evoked by short auditory stimuli. Electroencephalogr Clin Neurophysiol. 1985; 61(4):254-66. DOI: 10.1016/0013-4694(85)91092-2. View

16.

Wood F . Focal and diffuse memory activation assessed by localized indicators of CNS metabolism: the semantic-episodic memory distinction. Hum Neurobiol. 1987; 6(2):141-51. View

17.

Wise S, Mauritz K . Set-related neuronal activity in the premotor cortex of rhesus monkeys: effects of changes in motor set. Proc R Soc Lond B Biol Sci. 1985; 223(1232):331-54. DOI: 10.1098/rspb.1985.0005. View

18.

Sasaki K, Gemba H . Development and change of cortical field potentials during learning processes of visually initiated hand movements in the monkey. Exp Brain Res. 1982; 48(3):429-37. DOI: 10.1007/BF00238619. View

19.

Lang W, Lang M, Heise B, Deecke L, Kornhuber H . Brain potentials related to voluntary hand tracking, motivation and attention. Hum Neurobiol. 1984; 3(4):235-40. View

20.

Roland P, Friberg L . Localization of cortical areas activated by thinking. J Neurophysiol. 1985; 53(5):1219-43. DOI: 10.1152/jn.1985.53.5.1219. View