Enhancement of Human Immunodeficiency Virus Production by Natural Lymphotoxin

Overview

Journal Med Microbiol Immunol

Specialty Allergy & Immunology

Date 1988 Jan 1

PMID 3262193

Citations 9

Authors

T Matsuyama

Y Hamamoto

S Kobayashi

M Kurimoto

J Minowada

N Kobayashi

N Yamamoto

Affiliations

Soon will be listed here.

Abstract

The effect of natural lymphotoxin (n-LT) on CD4+ MOLT-4 cells and those cells producing human immunodeficiency virus (HIV), MOLT-4/HIVHTLV-IIIB cells, was studied. Four days after treatment with n-LT, a significant cytotoxic/cytostatic effect was observed predominantly on MOLT-4/HIVHTLV-IIIB cells. Furthermore, with regard to the production of HIV, an almost 3- to 5-fold increase of viral particles was observed in MOLT-4/HIVHTLV-IIIB cells 6 h after treatment with n-LT. These data indicate the possibility that this cytotoxic factor is one of the responsible molecules in the pathogenesis of the acquired immunodeficiency syndrome (AIDS).

Citing Articles

Pan-caspase inhibitors induce secretion of HIV-1 latency reversal agent lymphotoxin-alpha from cytokine-primed NK cells.

Hajikhezri Z, Zygouras I, Sonnerborg A, van Domselaar R Cell Death Discov. 2025; 11(1):44.

PMID: 39905001 PMC: 11794648. DOI: 10.1038/s41420-025-02330-1.

Membrane tumor necrosis factor (TNF) induced cooperative signaling of TNFR60 and TNFR80 favors induction of cell death rather than virus production in HIV-infected T cells.

Lazdins J, Grell M, Walker M, Scheurich P, Pfizenmaier K J Exp Med. 1997; 185(1):81-90.

PMID: 8996244 PMC: 2196100. DOI: 10.1084/jem.185.1.81.

The presence of HTLV-I proviral DNA in the central nervous system of patients with HTLV-I-associated myelopathy/tropical spastic paraparesis.

Kira J Mol Neurobiol. 1994; 8(2-3):139-45.

PMID: 7999310 DOI: 10.1007/BF02780664.

Tumor necrosis factor alpha activates human immunodeficiency virus type 1 through induction of nuclear factor binding to the NF-kappa B sites in the long terminal repeat.

Duh E, Maury W, Folks T, Fauci A, Rabson A Proc Natl Acad Sci U S A. 1989; 86(15):5974-8.

PMID: 2762307 PMC: 297754. DOI: 10.1073/pnas.86.15.5974.

Cytocidal effect of tumor necrosis factor on cells chronically infected with human immunodeficiency virus (HIV): enhancement of HIV replication.

Matsuyama T, Hamamoto Y, Soma G, Mizuno D, Yamamoto N, Kobayashi N J Virol. 1989; 63(6):2504-9.

PMID: 2470917 PMC: 250713. DOI: 10.1128/JVI.63.6.2504-2509.1989.

References

Miyoshi I, Hiraki S, Tsubota T, Kubonishi I, Matsuda Y, Nakayama T . Human B cell, T cell and null cell leukaemic cell lines derived from acute lymphoblastic leukaemias. Nature. 1977; 267(5614):843-4. DOI: 10.1038/267843a0. View

Minowada J, Onuma T, Moore G . Rosette-forming human lymphoid cell lines. I. Establishment and evidence for origin of thymus-derived lymphocytes. J Natl Cancer Inst. 1972; 49(3):891-5. View

Mestan J, Digel W, Mittnacht S, Hillen H, Blohm D, Moller A . Antiviral effects of recombinant tumour necrosis factor in vitro. Nature. 1986; 323(6091):816-9. DOI: 10.1038/323816a0. View

Yamazaki S, Onishi E, Enami K, Natori K, Kohase M, Sakamoto H . Proposal of standardized methods and reference for assaying recombinant human tumor necrosis factor. Jpn J Med Sci Biol. 1986; 39(3):105-18. DOI: 10.7883/yoken1952.39.105. View

Harada S, Koyanagi Y, Yamamoto N . Infection of HTLV-III/LAV in HTLV-I-carrying cells MT-2 and MT-4 and application in a plaque assay. Science. 1985; 229(4713):563-6. DOI: 10.1126/science.2992081. View

Ruddle N, Waksman B . Cytotoxicity mediated by soluble antigen and lymphocytes in delayed hypersensitivity. 3. Analysis of mechanism. J Exp Med. 1968; 128(6):1267-79. PMC: 2138574. DOI: 10.1084/jem.128.6.1267. View

Weitzen M, YAMAMOTO R, GRANGER G . Identification of human lymphocyte-derived lymphotoxins with binding and cell-lytic activity on NK-sensitive cell lines in vitro. Cell Immunol. 1983; 77(1):30-41. DOI: 10.1016/0008-8749(83)90004-7. View

Kondo L, Rosenau W, Wara D . Role of lymphotoxin in antibody-dependent cell-mediated cytotoxicity (ADCC). J Immunol. 1981; 126(3):1131-3. View

Ware C, GRANGER G . Mechanisms of lymphocyte-mediated cytotoxicity. III. Characterization of the mechanism of inhibition of the human alloimmune lymphocyte-mediated cytotoxic reaction by polyspecific anti-lymphotoxin sera in vitro. J Immunol. 1981; 126(5):1934-40. View

10.

Miyoshi I, Kubonishi I, Yoshimoto S, Akagi T, Ohtsuki Y, Shiraishi Y . Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukaemic T cells. Nature. 1981; 294(5843):770-1. DOI: 10.1038/294770a0. View

11.

Matsuyama T, Hamamoto Y, Yoshida T, Kido Y, Kobayashi S, Kobayashi N . Effect of culture supernatant of MT-2 cells on human immunodeficiency virus-producing cells, MOLT-4/HIVHTLV-IIIB cells. Jpn J Cancer Res. 1988; 79(2):156-9. PMC: 5917466. DOI: 10.1111/j.1349-7006.1988.tb01571.x. View

12.

CARSWELL E, Old L, Kassel R, Green S, Fiore N, Williamson B . An endotoxin-induced serum factor that causes necrosis of tumors. Proc Natl Acad Sci U S A. 1975; 72(9):3666-70. PMC: 433057. DOI: 10.1073/pnas.72.9.3666. View

13.

Harada S, Koyanagi Y, Nakashima H, Kobayashi N, Yamamoto N . Tumor promoter, TPA, enhances replication of HTLV-III/LAV. Virology. 1986; 154(2):249-58. DOI: 10.1016/0042-6822(86)90451-4. View

14.

Gray P, Aggarwal B, Benton C, Bringman T, Henzel W, Jarrett J . Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity. Nature. 1984; 312(5996):721-4. DOI: 10.1038/312721a0. View

15.

Wong G, Goeddel D . Tumour necrosis factors alpha and beta inhibit virus replication and synergize with interferons. Nature. 1986; 323(6091):819-22. DOI: 10.1038/323819a0. View

16.

Kikukawa R, Koyanagi Y, Harada S, Kobayashi N, Hatanaka M, Yamamoto N . Differential susceptibility to the acquired immunodeficiency syndrome retrovirus in cloned cells of human leukemic T-cell line Molt-4. J Virol. 1986; 57(3):1159-62. PMC: 252852. DOI: 10.1128/JVI.57.3.1159-1162.1986. View