» Articles » PMID: 32620315

Pharmacologic Management of Patients with Hepatic and Pancreatic Diseases That Involve Immunosuppressive Therapies. Position Statement Within the Framework of the SARS-CoV-2 (COVID-19) Pandemic

Overview
Specialty Gastroenterology
Date 2020 Jul 5
PMID 32620315
Citations 1
Authors
Affiliations
Soon will be listed here.
Abstract

The coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus2 (SARS-CoV-2) virus. COVID-19 affected more than 6million persons worldwide in fewer than 4 months, after the report of the first cases in China in December 2019. The relation of the disease caused by SARS-Cov-2 to immunosuppressive treatment used in different gastrointestinal disorders is uncertain, resulting in debate with regard to suspending immunosuppressive therapy to improve infection outcome. Said suspension implies the inherent risk for graft rejection or autoimmune disease exacerbation that can potentially worsen the course of the infection. Based on the presently available evidence, a treatment stance has been established for patients with gastrointestinal diseases that require immunosuppressive therapy.

Citing Articles

Coronavirus disease 2019 and the pancreas.

Samanta J, Gupta R, Singh M, Patnaik I, Kumar A, Kochhar R Pancreatology. 2020; 20(8):1567-1575.

PMID: 33250089 PMC: 7550073. DOI: 10.1016/j.pan.2020.10.035.

References
1.
Zhang C, Shi L, Wang F . Liver injury in COVID-19: management and challenges. Lancet Gastroenterol Hepatol. 2020; 5(5):428-430. PMC: 7129165. DOI: 10.1016/S2468-1253(20)30057-1. View

2.
Barmettler S, Ong M, Farmer J, Choi H, Walter J . Association of Immunoglobulin Levels, Infectious Risk, and Mortality With Rituximab and Hypogammaglobulinemia. JAMA Netw Open. 2019; 1(7):e184169. PMC: 6324375. DOI: 10.1001/jamanetworkopen.2018.4169. View

3.
Vikse J, Jonsdottir K, Kvaloy J, Wildhagen K, Omdal R . Tolerability and safety of long-term rituximab treatment in systemic inflammatory and autoimmune diseases. Rheumatol Int. 2019; 39(6):1083-1090. DOI: 10.1007/s00296-019-04272-1. View

4.
Fix O, Hameed B, Fontana R, Kwok R, McGuire B, Mulligan D . Clinical Best Practice Advice for Hepatology and Liver Transplant Providers During the COVID-19 Pandemic: AASLD Expert Panel Consensus Statement. Hepatology. 2020; 72(1):287-304. PMC: 7262242. DOI: 10.1002/hep.31281. View

5.
Ju C, Lian Q, Zhang J, Qiu T, Cai Z, Jiang W . Recommended prophylactic and management strategies for severe acute respiratory syndrome coronavirus 2 infection in transplant recipients. Chronic Dis Transl Med. 2020; 6(2):87-97. PMC: 7194659. DOI: 10.1016/j.cdtm.2020.02.003. View