Activity of Vitamin D Receptor Agonists Against Dengue Virus

Overview

Journal Sci Rep

Specialty Science

Date 2020 Jul 4

PMID 32616772

Citations 4

Authors

Janejira Jaratsittisin

Bin Xu

Wannapa Sornjai

Zhibing Weng

Atichat Kuadkitkan

Feng Li

Guo-Chun Zhou

Duncan R Smith

Affiliations

Soon will be listed here.

Abstract

Infections with the mosquito-transmitted dengue virus (DENV) are a pressing public health problem in many parts of the world. The recently released commercial vaccine for DENV has encountered some problems, and there is still no effective drug to treat infections. Vitamin D has a well characterized role in calcium and phosphorus homeostasis, but additionally has a role in the immune response to bacterial and viral pathogens. In this study a number of fused bicyclic derivatives of 1H-pyrrolo[1,2]imidazol-1-one with vitamin D receptor (VDR) agonist activity were evaluated for possible anti-DENV activity. The results showed that five of the compounds were able to significantly inhibit DENV infection. The most effective compound, ZD-3, had an EC value of 7.47 μM and a selective index of 52.75. The compounds were only effective when used as a post-infection treatment and treatment significantly reduced levels of infection, virus output, DENV protein expression and genome copy number. These results suggest that these VDR agonists have the potential for future development as effective anti-DENV agents.

Citing Articles

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