Generation of Non-MHC Restricted Killing in Cultures Stimulated with B Cells from Chronic Lymphocytic Leukaemia Patients: Phenotypic Characterization of the Precursor and Effector Cells

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1988 May 1

PMID 3261664

Citations 1

Authors

L Matera

R Foa

F Malavasi

G Bellone

A Funaro

F Veglia

D Santoli

Affiliations

Soon will be listed here.

Abstract

Freshly isolated B cells from chronic lymphocytic leukaemia patients (B-CLL) have been previously shown to induce a strong proliferative response and high levels of NK-like activity in lymphocytes from healthy donors. The present paper deals with the origin, mitotic state, target spectrum and cell surface phenotype of the NK-like effectors generated after stimulation with B-CLL. Experiments using large granular lymphocytes (LGL) and T cells as responders demonstrated that most of the precursors of the newly generated NK-like effectors express the CD3 antigen. The induction of NK-like activity paralleled cell activation, as judged by blast transformation, thymidine uptake and appearance of cell surface activation markers. The newly generated NK-like effectors displayed a T cell phenotype and a broader target repertoire than native NK cells.

Citing Articles

B cells from chronic lymphocytic leukemia (CLL) patients are strong inducers of proliferation and major histocompatibility complex (MHC)-unrestricted [natural killer (NK)-like] cytotoxicity in normal T-lymphocytes.

Matera L, Foa R, Massaia M, Giovarelli M, Veglia F, Cesano A J Clin Immunol. 1989; 9(4):329-37.

PMID: 2475521 DOI: 10.1007/BF00918665.

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