Protein-Based Nanoparticles As Drug Delivery Systems

Overview

Journal Pharmaceutics

Publisher MDPI

Date 2020 Jul 3

PMID 32610448

Citations 133

Authors

Seyoung Hong

Dong Wook Choi

Hong Nam Kim

Chun Gwon Park

Wonhwa Lee

Hee Ho Park

Affiliations

Soon will be listed here.

Abstract

Nanoparticles have been extensively used as carriers for the delivery of chemicals and biomolecular drugs, such as anticancer drugs and therapeutic proteins. Natural biomolecules, such as proteins, are an attractive alternative to synthetic polymers commonly used in nanoparticle formulation because of their safety. In general, protein nanoparticles offer many advantages, such as biocompatibility and biodegradability. Moreover, the preparation of protein nanoparticles and the corresponding encapsulation process involved mild conditions without the use of toxic chemicals or organic solvents. Protein nanoparticles can be generated using proteins, such as fibroins, albumin, gelatin, gliadine, legumin, 30Kc19, lipoprotein, and ferritin proteins, and are prepared through emulsion, electrospray, and desolvation methods. This review introduces the proteins used and methods used in generating protein nanoparticles and compares the corresponding advantages and disadvantages of each.

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