Identifying Novel Genetic Alterations in Pediatric Acute Lymphoblastic Leukemia Based on Copy Number Analysis

Overview

Journal Mol Cytogenet

Publisher Biomed Central

Specialty Biochemistry

Date 2020 Jul 2

PMID 32607130

Authors

Jessica Almeida Batista-Gomes

Fernando Augusto Rodrigues Mello Jr

Edivaldo Herculano Correa de Oliveira

Michel Platini Caldas de Souza

Alayde Vieira Wanderley

Laudreisa da Costa Pantoja

Ney Pereira Carneiro Dos Santos

Bruna Claudia Meireles Khayat

Andre Salim Khayat

Affiliations

Soon will be listed here.

Abstract

Copy number variations (CNVs) analysis may reveal molecular biomarkers and provide information on the pathogenesis of acute lymphoblastic leukemia (ALL). We investigated the gene copy number in childhood ALL by microarray and select three new recurrent CNVs to evaluate by real-time PCR assay: , and were selected due to high frequency of CNVs in ALL samples and based on their potential biological functions in carcinogenesis described in the literature. deletion was associated with patients with chromosomal translocations and is a potential tumor suppressor; and may act as an oncogene despite having a paradoxical behavior in carcinogenesis. This study reinforces that microarrays/aCGH is it is a powerful tool for detection of genomic aberrations, which may be used in the risk stratification.

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